基本属性 生物活性靶点体外研究体内研究 用途与合成方法 西立伐他汀钠 价格(试剂级) 供应商 供应信息 相关产品
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西立伐他汀钠

西立伐他汀钠

中文名称:西立伐他汀钠
英文名称:Cerivastatin sodium
CAS号:143201-11-0
分子式:C26H35FNNaO5
分子量:483.56
EINECS号:
Mol文件:143201-11-0.mol
西立伐他汀钠 结构式

西立伐他汀钠 性质

熔点 197-199°C
比旋光度 D20 +24.1° (c = 1 in ethanol)
储存条件 Hygroscopic, Store under Inert atmosphere -20°C Freezer
溶解度 H2O:≥5mg/mL
形态 粉末
颜色 白色至棕褐色
旋光性 (optical activity) [α]/D +18 to +26° in ethanol
稳定性 吸湿性
CAS 数据库 143201-11-0(CAS DataBase Reference)

西立伐他汀钠 用途与合成方法

Cerivastatin sodium 是一种合成的降脂剂,是一种高效,耐受性好,口服活性的 HMG-CoA 还原酶抑制剂,Ki 为 1.3 nM/L。Cerivastatin sodium 可降低低密度脂蛋白胆固醇水平。Cerivastatin sodium 还主要通过 RhoA 抑制作用来抑制 MDA-MB-231 细胞的增殖和侵袭,具有抗癌作用。

Ki: 1.3 nM/L (HMG-CoA reductase)

Cerivastatin (5-50 ng/mL; 3 days; MDA-MB-231 cells) treatment induces a dose-dependent decrease in cell proliferation of MDA-MB-231 cells (up to 40% inhibition at 25 ng/mL).
Cerivastatin (25 ng/mL; 18-36 hours; MDA-MB-231 cells) treatment induces an arrest of the cell cycle in G 1/S phase after 36 h treatment. This arrest is not observed for a shorter incubation time (18 h).
Cerivastatin (25 ng/mL; 18 hours; MDA-MB-231 cells) treatment induces a marked increase in the level of p21 Waf1/Cip1 .
Cerivastatin (25 ng/mL; 12 hours; MDA-MB-231 cells) treatment increases the p21 transcript in MDA-MB-231 cells.
Cerivastatin (10-25 ng/mL; 18 hours) inhibits invasion of MDA-MB-231 cells through Matrigel.
Cerivastatin (25 ng/mL; 18-36 hours) delocalizes RhoA and Ras from the membrane to the cytosol and induces morphological changes.
Cerivastatin (25 ng/mL; 4-36 hours) induces inactivation of NFκB, in a RhoA inhibition-dependent manner, resulting in a decrease in urokinase and metalloproteinase-9 expression, and concomitantly increases IκB.

Cell Proliferation Assay

Cell Line: MDA-MB-231 cells
Concentration: 5 ng/mL, 10 ng/mL, 25 ng/mL, 50 ng/mL
Incubation Time: 3 days
Result: Induced a dose-dependent decrease in cell proliferation of MDA-MB-231 cells.

Cell Cycle Analysis

Cell Line: MDA-MB-231 cells
Concentration: 25 ng/mL
Incubation Time: 18 hours, 36 hours
Result: Induced a cell cycle block in G 1/S phase.

Western Blot Analysis

Cell Line: MDA-MB-231 cells
Concentration: 25 ng/mL
Incubation Time: 18 hours
Result: Induced a marked increase in the level of p21 Waf1/Cip1 .

RT-PCR

Cell Line: MDA-MB-231 cells
Concentration: 25 ng/mL
Incubation Time: 12 hours
Result: Increased p21 Waf1/Cip1 mRNA levels.

Cerivastatin is well absorbed, reaching maximal plasma levels in 1-3 hours following oral dosing. In the circulation, Cerivastatin is highly bound to plasma proteins (99.5%), with an elimination half-life of 2-4 hours. Cerivastatin is metabolized predominantly in the liver to three polar metabolites. Two of these metabolites are active, but to a lesser extent compared to parent drug, and the third metabolite is inactive. Plasma concentrations of all metabolites are substantially lower than those of the parent drug. Elimination of metabolites is via the urine (20-25%) and feces (66-73%), while essentially no parent compound is excreted.

安全信息

WGK Germany3

西立伐他汀钠 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-109523 1 mg 636
2024-11-08 HY-109523 西立伐他汀钠 143201-11-0 5mg 1400

西立伐他汀钠供应商 更多

北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
中文名称:西立伐他汀,钠盐
英文名称:Cerivastatin, SodiuM Salt
CAS:143201-11-0
包装信息:100Mg,10Mg,5Mg
备注:化学试剂、精细化学品、医药中间体、材料中间体
广州爱纯医药科技有限公司
联系电话:020-39119399 18927568969
产品介绍:
中文名称:西立伐他汀钠
英文名称:Cerivastatin sodium salt hydrate
CAS:143201-11-0
纯度:98% (HPLC)
包装信息:5MG; 25MG; 100MG; 1G
备注:品牌:StdSun | 提供定制合成服务(包括:小分子,药物杂质及医药中间体)
武汉丰泰威远科技有限公司
联系电话:027-87465837 19945049750
产品介绍:
中文名称:西立伐他汀钠
英文名称:Cerivastatin sodium
CAS:143201-11-0
纯度:98%
包装信息:1g,10g,25g,100g,500g,1kg
备注:试剂级
上海创赛科技有限公司
联系电话:400-6087598 15021221957
产品介绍:
中文名称:Perfemiker]西立伐他汀钠,98%
英文名称:Cerivastatin sodium
CAS:143201-11-0
纯度:98%
包装信息:5mg;1mg
江苏艾康生物医药研发有限公司
联系电话:025-66113011 18112977050
产品介绍:
英文名称:Cerivastatin sodium
CAS:143201-11-0
纯度:95+%
包装信息:1g;5g;10g

最新发布供应信息

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TargetMol中国(陶术生物) 2024-09-29
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