ChemicalBook Product Catalog API Nervous system drugs Other nervous system drugs D-METHAMPHETAMINE

D-METHAMPHETAMINE

Chemical Properties

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	16-36/37-45
RIDADR	1851
WGK Germany	1
HazardClass	6.1(b)
PackingGroup	III
Hazardous Substances Data	537-46-2(Hazardous Substances Data)
Toxicity	A widely abused drug; a sympathomimetic and central stimulant that has been used clinically as an anorectic agent. The use of methamphetamine and related drugs in treating obesity is, however, now generally discredited. It may cause elevation of blood pressure, palpitation, and tachycardia, as well as various CNS effects, including psychotic effects at higher doses. Chronic use of methamphetamine and related compounds, especially at high doses as often occurs with drug abuse, can cause a condition often indistinguishable from schizophrenia. Abrupt withdrawal may cause fatigue, depression, and sleep changes. Methamphetamine is an indirect-acting adrenergic and dopamine agonist that acts principally to release endogenous catecholamines, thereby increasing their synaptic availability. Many of its actions can be blocked by adrenergic and dopamine antagonists. The i.p. LD50 in mice is 70 mg/kg.