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10,11-Dimethoxystrychnine Basic information
10,11-Dimethoxystrychnine Chemical Properties
  • Melting point:175-178 °C (dec.)(lit.)
  • alpha -118 º (c=2.5 in chloroform)
  • Boiling point:518.67°C (rough estimate)
  • Density 1.2119 (rough estimate)
  • refractive index 1.6300 (estimate)
  • storage temp. Store at RT
  • pka8.28(at 25℃)
  • form Powder
  • color White to light beige
  • Water Solubility Soluble in alcohol, chloroform, and benzene, slightly soluble in water, ether, and glycerol
  • Merck 14,1455
  • Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference357-57-3(CAS DataBase Reference)
  • NIST Chemistry ReferenceBrucine(357-57-3)
  • EPA Substance Registry SystemBrucine (357-57-3)
Safety Information
10,11-Dimethoxystrychnine Usage And Synthesis
  • Chemical PropertiesWhite powder
  • Uses10,11-Dimethoxystrychnine can be used for antineoplastic, convulsant.
  • UsesBrucine occurs in the seeds of strychnosspecies (Strychnos nux vomica L. and otherspecies). It is used for denaturing alcoholsand oils; for separating racemic mixtures;and as an additive to lubricants. It is alsoused for colorimetric analysis of nitrate.Therapeutically, it is used as a stimulant.
  • General DescriptionA white crystalline solid. Combustible but may require some effort to ignite. Toxic by inhalation (vapor, dust, etc.) and ingestion.
  • Air & Water ReactionsSlightly soluble in water.
  • HazardPoison by ingestion and inhalation.
  • Health HazardThe toxicity of brucine is similar to that ofstrychnine. It is a very poisonous alkaloid. Itis a strong convulsant; excites all portions ofthe central nervous system. Toxic symptomsinclude headache, tremor, muscular rigidity,and convulsions. Death may occur fromrespiratory arrest after a few convulsions.
    LD50 value, subcutaneous (mice): 60 mg/kg.
  • Health HazardChemical is toxic if inhaled, swallowed, or absorbed through skin. Inhalation produces intense bitter taste. Ingestion causes nausea, vomiting, restlessness, excitement, twitching, and (rarely) convulsions. Contact with dust irritates eyes.
  • Fire HazardSpecial Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.
  • Agricultural UsesRodenticide: Used in the manufacture of other chemicals, in perfumes, as a medication for animals, and as a poison for rodents
  • Safety ProfileA poison by subcutaneous, intravenous, and intraperitoneal routes. An alkaloid-like strychnine, but one-sixth as toxic. When heated to decomposition it emits toxic fumes of Nx,. See also STRYCHNINE
  • Purification MethodsCrystallise brucine once from water or aqueous Me2CO (as the tetrahydrate), then suspend it in CHCl3 and shake with anhydrous Na2SO4 (to dehydrate the brucine, which then dissolves). Precipitate it by pouring the solution into a large bulk of dry pet ether (b 40-60o), filter and heat to 120o in a high vacuum [Turner J Chem Soc 842 1951]. The tetrahydrate crystallises from a mixture of EtOH and H2O as colourless elongated needles [Eeles Acta Cryst 6 809 1953, Beilstein 27 III/IV 7875.] VERY POISONOUS
10,11-Dimethoxystrychnine Preparation Products And Raw materials
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