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D-TUBOCURARINE CHLORIDE

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D-TUBOCURARINE CHLORIDE Basic information
D-TUBOCURARINE CHLORIDE Chemical Properties
  • Melting point:274~275℃
  • alpha D20-25 +215° (c = 0.25-0.3 g/100 ml)
  • Density 1.2074 (rough estimate)
  • refractive index 1.7350 (estimate)
  • storage temp. 2-8°C
  • pkapK: 7.4(at 25℃)
Safety Information
  • Hazard Codes T
  • Risk Statements 25
  • Safety Statements 45
  • RIDADR UN 1544 6.1/PG 2
  • WGK Germany 3
  • RTECS YO4900000
  • HazardClass 6.1(b)
  • PackingGroup III
  • ToxicityLD50 in mice, rats (mg/kg): 33.2, 27.8 orally in DMSO; 59.5, 36.9 orally in water (Rosen)
MSDS
D-TUBOCURARINE CHLORIDE Usage And Synthesis
  • Chemical PropertiesWhite to light-tan crystalline alkaloid; odorless. Mp 270C with decomposition. Soluble in water and alcohol; insoluble in acetone, chloroform, and ether; aqueous solution is strongly dextrorotatory (specific rotation for 1% solution of anhydrous ?208 to +218 degrees).
  • UsesNeuromuscular blocking agent.
  • HazardHighly toxic.
  • Biological ActivityCompetitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT 3 and GABA A receptor antagonist.
  • Safety ProfilePoison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human toxicity: Large doses and overdoses may cause respiratory paralysis and hypotension. When heated to decomposition it emits very toxic fumes of NOx and Cl-. Used as a muscle relaxant.
  • Purification MethodsCrystallise this chloride from water. It forms various hydrates. The hydrochloride pentahydrate has m 268-269o (from H2O) and [] D +190o (0.5, H2O). Its solubility in H2O at 25o is 50mg/mL. [Beilstein 27 II 897, 27 III/IV 8727.]
D-TUBOCURARINE CHLORIDE(57-94-3)Related Product Information
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