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(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE Structure

(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE

Chemical Properties

Boiling point bp0.4 100-110°
Density  1.100±0.06 g/cm3(Predicted)
Flash point 9℃
storage temp.  2-8°C
pka 10.32±0.10(Predicted)
InChIKey SHXWCVYOXRDMCX-UHFFFAOYSA-N
EPA Substance Registry System 1,3-Benzodioxole-5-ethanamine, N,.alpha.-dimethyl- (42542-10-9)

Safety Information

Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  7-16-36/37-45
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
Hazardous Substances Data 42542-10-9(Hazardous Substances Data)
Toxicity A novel psychoactive drug chemically related to the hallucinogenic agent MDA, but reported to be non-hallucinogenic. Obtained by direct synthesis, at high doses it is reported to show a stimulant-like effect in animals. Its LD50 is 97 mg/kg, i. p., 49 mg/kg, i.p., 14 mg/kg, i.v., and 22 mg/kg, i.v. in mice, rats, dogs, and monkeys, respectively. At higher doses, MDMA has pressor effects and produces tachycardia, and causes damage to serotonin neurons in both rats and monkeys. The (S)- (1)-enantiomer is more active than the (R)-(?′)-enantiomer and, like amphetamine, the pharmacological effects may be due to a release of endogenous monoamine neurotransmitter, probably serotonin and/or norepinephrine. MDMA is also an inhibitor of monoamine uptake into brain synaptosomes. Symptoms include pronounced mydriasis, with nystagmus and jaw clenching, and nausea also is often reported. This substance produces a feeling of well-being and euphoria and is similar in some respects to MDA, in that it seems to enhance a sense of empathy and emotional openness in users. Toxic reactions would appear to occur as a result of the pressor action, and sympathomimetic effects of the drug. No appropriate therapeutic intervention has been reported. Peripheral adrenergic blocking agents, or chlorpromazine, have been used, however, to prevent death in dogs following a lethal i.v. dose of the chemically related agent MDA.

Usage And Synthesis

Preparation Products And Raw materials

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