(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE
- Product Name(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE
- CAS42542-10-9
- CBNumberCB4221584
- MFC11H15NO2
- MW193.25
- EINECS200-659-6
- MDL NumberMFCD00287291
- MOL File42542-10-9.mol
Chemical Properties
| Boiling point | bp0.4 100-110° |
| Density | 1.100±0.06 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| pka | 10.32±0.10(Predicted) |
| InChIKey | SHXWCVYOXRDMCX-UHFFFAOYSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | KE1SEN21RM |
| NCI Drug Dictionary | 3,4-methylenedioxymethamphetamine |
| EPA Substance Registry System | 1,3-Benzodioxole-5-ethanamine, N,.alpha.-dimethyl- (42542-10-9) |
Safety
| Symbol(GHS) |
  
|
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310-P311 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| Hazardous Substances Data | 42542-10-9(Hazardous Substances Data) |
| Toxicity | A novel psychoactive drug chemically related to the hallucinogenic agent MDA, but reported to be non-hallucinogenic. Obtained by direct synthesis, at high doses it is reported to show a stimulant-like effect in animals. Its LD50 is 97 mg/kg, i. p., 49 mg/kg, i.p., 14 mg/kg, i.v., and 22 mg/kg, i.v. in mice, rats, dogs, and monkeys, respectively. At higher doses, MDMA has pressor effects and produces tachycardia, and causes damage to serotonin neurons in both rats and monkeys. The (S)- (1)-enantiomer is more active than the (R)-(?′)-enantiomer and, like amphetamine, the pharmacological effects may be due to a release of endogenous monoamine neurotransmitter, probably serotonin and/or norepinephrine. MDMA is also an inhibitor of monoamine uptake into brain synaptosomes. Symptoms include pronounced mydriasis, with nystagmus and jaw clenching, and nausea also is often reported. This substance produces a feeling of well-being and euphoria and is similar in some respects to MDA, in that it seems to enhance a sense of empathy and emotional openness in users. Toxic reactions would appear to occur as a result of the pressor action, and sympathomimetic effects of the drug. No appropriate therapeutic intervention has been reported. Peripheral adrenergic blocking agents, or chlorpromazine, have been used, however, to prevent death in dogs following a lethal i.v. dose of the chemically related agent MDA. |
