Description
The full structure of harringtonine has now been established from a study of the
hydrolysis products of this base.
Description
Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations. It immobilizes ribosomes immediately after the initiation of translation. While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia. The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-
protected mRNA fragments for evaluating translation.
Chemical Properties
White Solid
Uses
A natural product with significant antitumor activities.
Uses
specific anti-leukemia drug
Definition
ChEBI: Harringtonine is an alkaloid.
References
Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972)
Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973)
