DL-Alaninol

2902-96-7

6168-72-5

The general procedure for the synthesis of DL-aminopropanol from 2-nitro-1-propanol was carried out as follows: to an acetonitrile solution of 2-nitro-1-propanol (1 mmol / eq) was added DIPEA (5 mmol / eq) at 15 °C, stirring was maintained. Subsequently, freshly distilled trichlorosilane (3.5 mmol / eq) was added slowly dropwise using a syringe. The reaction mixture was stirred continuously at 15°C for 18 hours. Upon completion of the reaction, the reaction was quenched by addition of 10% NaOH solution and the mixture was extracted with ethyl acetate (AcOEt). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum to give DL-aminopropanol in quantitative yield.