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4-DiMethylaMino Antipyrine

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4-DiMethylaMino Antipyrine Basic information
4-DiMethylaMino Antipyrine Chemical Properties
  • Melting point:107-109 °C(lit.)
  • Boiling point:373.38°C (rough estimate)
  • Density 1.0744 (rough estimate)
  • refractive index 1.6140 (estimate)
  • storage temp. Refrigerator
  • pkapKa 5.0 (Uncertain)
  • form Crystalline Powder, Crystals and/or Chunks
  • color Off-white to brownish
  • Water Solubility 5.55 g/100 mL
  • Sensitive Air & Light Sensitive
  • Merck 14,474
  • Stability:Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
  • InChIKeyRMMXTBMQSGEXHJ-UHFFFAOYSA-N
  • CAS DataBase Reference58-15-1(CAS DataBase Reference)
  • NIST Chemistry ReferenceAminopyrine(58-15-1)
  • EPA Substance Registry SystemAminopyrine (58-15-1)
Safety Information
MSDS
4-DiMethylaMino Antipyrine Usage And Synthesis
  • Chemical Propertieswhite crystalline powder
  • UsesAntipyretic; analgesic.
  • UsesAntipyretic;ACTH secretor
  • DefinitionChEBI: A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic proper ies.
  • brand nameAdexogan;Agevis;Algimicin anttitermico;Amidazopen;Amidozen;Anoixal;Antigripina;Areumal;Axiston;Balbion;Barsedan;Baukal suppositories;Bayer 1387 p;Bronchisan;Brufaneuseol;Butapyrine;Capsyka dr knapf;Capysal;Chinopyrin;Cibalgin;Ciclazon;Clinit;Coffan;Compral;Cusayth;Demolpas;Dentigoa;Depiral c;Dexa escopyrin;Dha 51;Dialpyrin;Digisab;Dimametten;Dimopyrin;Diprin;Dolo-attirin;Dolo-optineural;Dolorphen;Dolovosano;Donobin;Duerin;Dysmensan;Escopyrinus;Espasnatex;Eufibran;Euprogan;Febren;Febrosolvin;Fenodone;Fever;Flivalgin;Flumil;Framidone;Ftalazon;Funapon;Galenopyrin;Glucopirina;Glucopitina;Helvagit-f;Hemicraneal;Hisense-p;Influnal depot;Inst;Irgapyrine;Isoftal;Kalmine;Katareuma;Lagaflex;Latepyrine;Lauroanginol;Manslu;Medispanmin;Meloka;Neuro-demoplast;Nifedon;Nikartrone;Nostress;Optineural(analgesic);Optipax;Osadrine;Osmotipax;P.s.b.p.;Piracodid;Piradenil;Piradol;Pirasco;Piraseptolo.
  • World Health Organization (WHO)Aminophenazone, a pyrazolone derivative, has been used as an antiinflammatory and analgesic agent for over a century. Its use has been associated with cases of bone marrow depression and agranulocytosis and more recently it has been claimed to have a carcinogenic potential. Products containing aminophenazone have been formally withdrawn in many countries and marketing has been voluntarily suspended in others. Elsewhere, however, proprietary preparations containing this ingredient may remain available. (Reference: (WHODI) WHO Drug Information, 3, 9, 1977)
  • General DescriptionSmall colorless crystals or white crystalline powder. Aqueous solution slightly alkaline to litmus. pH (5% water solution) 7.5-9. Odorless. Slightly bitter taste.
  • Air & Water ReactionsWater soluble.
  • Reactivity ProfileAminophenazone is sensitive to exposure to light. Aminophenazone is readily attacked by mild oxidizing agents in the presence of water. Aminophenazone is incompatible with acacia, apomorphine, aspirin, chloral hydrate, iodine and tannic acid.
  • Fire HazardFlash point data for Aminophenazone are not available; however, Aminophenazone is probably combustible.
  • Safety ProfileHuman poison by unspecified route. Experimental poison by ingestion, subcutaneous, intramuscular,intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic and reproductive effects. Questionable carcinogen when mixed with NaNO2 (1:l). Mutation data reported. Can cause bone marrow depression resulting in leucopenia. Has been implicated in development of aplastic anemia. A tranquilizer. When heated to decomposition it emits toxic fumes of NOx.
  • Purification MethodsIt crystallises from pet ether, sublimes between 80o and 90o, and forms metal complexes. [Beilstein 25 H 452, 25 III/IV 3555.]
4-DiMethylaMino Antipyrine Preparation Products And Raw materials
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