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Halobetasol propionate

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Halobetasol propionate Basic information
Halobetasol propionate Chemical Properties
  • Melting point:213-215°C
  • Boiling point:570.7±50.0 °C(Predicted)
  • Density 1.31±0.1 g/cm3(Predicted)
  • storage temp. Refrigerator
  • pka12.55±0.70(Predicted)
  • CAS DataBase Reference66852-54-8(CAS DataBase Reference)
Safety Information
  • HS Code 2937220000
MSDS
Halobetasol propionate Usage And Synthesis
  • DescriptionHalobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both antiinflammatory and antihyperplasia properties. The compound is recommended for the treatment of moderate to severe corticosteroid-responsive dermatoses and appears to be particularly effective in patients with plaque psoriasis.
  • DescriptionHalobetasol propionate is a synthetic glucocorticoid. It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.
  • Chemical PropertiesWhite Solid
  • OriginatorCiba-Geigy (Switzerland)
  • UsesAnti-inflammatory; a dermatologic agent commonly used to treat psoriasis
  • brand nameUltravate (Westwood-Squibb).
Halobetasol propionate Preparation Products And Raw materials
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