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Coumarin 151

Basic information Safety Related Supplier
Coumarin 151 Basic information
Coumarin 151 Chemical Properties
  • Melting point:221-222 °C(lit.)
  • Boiling point:314.6±42.0 °C(Predicted)
  • Density 1.4096 (estimate)
  • storage temp. Keep in dark place,Inert atmosphere,2-8°C
  • pka1.12±0.20(Predicted)
  • form Powder
  • color Yellow
  • Water Solubility Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.
  • BRN 4456797
  • CAS DataBase Reference53518-15-3(CAS DataBase Reference)
  • EPA Substance Registry System2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)- (53518-15-3)
Safety Information
  • Hazard Codes Xi,Xn
  • Risk Statements 36/37/38-20/21/22
  • Safety Statements 26-36-37/39
  • WGK Germany 3
  • Hazard Note Irritant
  • TSCA T
  • HazardClass IRRITANT
  • HS Code 29322090
MSDS
Coumarin 151 Usage And Synthesis
  • Chemical PropertiesCoumarin 151 is yellow powder
  • UsesCoumarin 151  is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.
  • Uses7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.
  • Purification MethodsPurify the coumarin by column chromatography on a C18 column, elute with acetonitrile/0.01M H2O/HCl (1:1), and recrystallise it from isopropanol. Alternatively, it is eluted from a silica gel column with CH2Cl2, or by extracting a CH2Cl2 solution (4g/L) with 1M aqueous NaOH (3 x 0.1L), followed by drying (MgSO4), filtration and evaporation. [Bissell J Org Chem 45 2283 1980, Zimmermann et al. Anal Biochem 70 258 1976.]
Coumarin 151 Preparation Products And Raw materials
Coumarin 151(53518-15-3)Related Product Information
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