53518-15-3
基本信息
香豆素 151
7-氨基-4-氟甲醇
香豆素490
7-AMINO-4-TRIFLUOROMETHYL-CHROMEN-2-ONE
7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN
AFC
AKOS B000459
BUTTPARK 20\02-79
COUMARIN 151
7-amino-4-(trifluoromethyl)-2h-1-benzopyran-2-on
7-amino-4-(trifluoromethyl)-2-benzopyrone
Coumarin 490
7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN, FOR FLUORESCENCE
7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN, 99+ %
Caspase 8 Fluorometric Substrate, IETD-AFC (FLICE, MASH, Mch5, N-acetyl-Asp-Glu-Val-Asp-AFC
Coumarin 151, laser grade, pure, 99%
7-Amino-4-(trifluoromethyl)coumarin 99%
Coumarine151
7-Amino-4-(trifluoromethyl)-2H-1-benzopyran-2-one
Coumarin 490. Coumarin 15
COUMARIN 151, 99%, LASER GRADE, PURE
物理化学性质
| 熔点 | 221-222 °C(lit.) |
| 沸点 | 314.6±42.0 °C(Predicted) |
| 密度 | 1.4096 (estimate) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 酸度系数(pKa) | 1.12±0.20(Predicted) |
| 形态 | 粉末 |
| 颜色 | 黄色 |
| 水溶解性 | Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water. |
| 检测方法 | HPLC |
| BRN | 4456797 |
| CAS 数据库 | 53518-15-3(CAS DataBase Reference) |
| EPA化学物质信息 | 2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)- (53518-15-3) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| 危险品标志 | Xi,Xn |
| 危险类别码 | R36/37/38-R20/21/22 |
| 安全说明 | S26-S36-S37/39 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| TSCA | T |
| 危险等级 | IRRITANT |
| 海关编码 | 29322090 |
图谱信息
香豆素 151(53518-15-3)质谱(MS)香豆素 151(53518-15-3)核磁图(1HNMR)香豆素 151(53518-15-3)核磁图(13CNMR)香豆素 151(53518-15-3)红外图谱(IR1)香豆素 151(53518-15-3)红外图谱(IR2)香豆素 151(53518-15-3)Raman光谱知名试剂公司产品信息
Coumarin 151, laser grade, pure, 99%(53518-15-3) Acros Organics
香豆素 151价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | A18400 | 7-氨基-4-三氟甲基香豆素 7-Amino-4-(trifluoromethyl)coumarin | 53518-15-3 | 0.25g | 332元 |
| 2024/11/08 | A18400 | 7-氨基-4-三氟甲基香豆素, 99%
7-Amino-4-(trifluoromethyl)coumarin, 99% | 53518-15-3 | 1g | 982元 |
| 2024/11/08 | XW025351815304 | 7-氨基-4-三氟甲基香豆素 | 53518-15-3 | 5G | 479元 |
常见问题列表
Amino acid and peptide derivatives of 7-amino-4-(trifluoromethyl)coumarin are used to monitor peptidase activities. Caspase activation is measured using the fluorogenic compound N-acetyl-asp-glu-val-asp-7-Amino-4-(trifluoromethyl)coumarin (Ac-DEVD-AFC). This substrate rapidly enters cells where it is efficiently cleaved at the aspartate residue by specific caspases, yielding the fluorescent compound 7-Amino-4-(trifluoromethyl)coumarin (AFC). Following cell disruption, released 7-Amino-4-(trifluoromethyl)coumarin is separated on HPLC and detected by fluorescence. The appearance of 7-Amino-4-(trifluoromethyl)coumarin in cells is blocked by the pancaspase inhibitor benzyloxycarbonyl-val-ala-asp-fluoromethylketone, thus establishing that intracellular caspases are responsible for the cleavage. γ-glutamyl-7-amino-4-(trifluoro-methyl)coumarin is synthesized and used as a substrate for fluirimetric assay of γ-gluta-myltranspeptidase. The reaction product 7-amino-4-(trifluoromethyl)coumarin is fluorescent at neutral pH values and with excitation and emission wavelengths of 400 and 490 nm, respectively, concentration is linearly related to fluorescence over the range of 10 to 300 pmol/3 mL reaction mixture.