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Coumarin 120

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Coumarin 120 Basic information
Coumarin 120 Chemical Properties
  • Melting point:223-226 °C (lit.)
  • Boiling point:306.47°C (rough estimate)
  • Density 1.1999 (rough estimate)
  • refractive index 1.5060 (estimate)
  • storage temp. 2-8°C
  • solubility Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide.
  • form Crystalline Powder
  • pka1.89 ± 0.20, most basic, temperature: 25 °C
  • color Beige to brown
  • Sensitive Light Sensitive
  • λmax351 nm (MeOH); 342 nm (Buffer pH 7)
  • BRN 142231
  • Major ApplicationFor authentification; dyelasers; color display devices; inks;monitoring underlying corrosion on coated aluminum;photoinitiating systems; recording materials;semiconductor devices; dye-sensitized solar cells(DSCs); mesoporous silica fibers; SiO2 sonogelhybrid materials; textiles; waveguides;whitening agents,
  • Biological ApplicationsIdentifyingbacteria; measuring urinary kallikrein levels;monitoring platinum(iv) reduction and platinum(ii)reactions in cancer cells; as a substrate for measuringadipinylamidases activity, aromatic amino aciddecarboxylases activity, histone deacetylasesactivity, hydrolases/esterases activity,β-lactamases activity, microbial nitroreductasesactivity, penicillin G acylases activity,proteases/proteinases/peptidases activity,glutamyltransferases activity, tryptophanasesactivity; as an effective antitubercular agent; use astemperature sensor,
  • InChIKeyGLNDAGDHSLMOKX-UHFFFAOYSA-N
  • CAS DataBase Reference26093-31-2(CAS DataBase Reference)
  • NIST Chemistry ReferenceCoumarin, 7-amino-4-methyl-(26093-31-2)
  • EPA Substance Registry System2H-1-Benzopyran-2-one, 7-amino-4-methyl- (26093-31-2)
Safety Information
MSDS
Coumarin 120 Usage And Synthesis
  • Chemical PropertiesCoumarin 120 is Light yellow beige powder
  • UsesCoumarin 120 is widely used fluorophore, well-known for preparing fluorogenic substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.
  • Usessuitable for determining polygalacturonase activity
  • Usesλ max 354 nm in EthanolSuitable as laser dye and used as a fluorescent labeling reagent for trace determination of enzymes.
  • General Description
    7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O.
  • Purification MethodsDissolve it in 5% HCl, filter and basify with 2M ammonia. The precipitate is dried in a vacuum and recrystallised from dilute EtOH. It yields a blue solution and is light sensitive. [Sigler Synthesis 614 1980, Kanaoka et al. Chem Pharm Bull Jpn 30 1485 1982, Beilstein 18/11 V 445.]
Coumarin 120 Preparation Products And Raw materials
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