5-Chloromethyl-1H-tetrazole

5-Methyltetrazole can be used in the synthesis of new-generation cephalosporin antibiotics. Its intermediates have wide applications in the synthesis of antifungal drugs and also have wide applications in the electronics field.

Steps for the aqueous phase synthesis of 5-chloromethyl-1H-tetrazole: 1. Put sodium azide, acetonitrile, zinc chloride and appropriate amount of deionized water into the atmospheric pressure reaction equipment for the reaction, after the end of the reaction to get 5-phenyltetrazole zinc salt; 2. 5-phenyltetrazole zinc salt obtained in step (1) in the dropwise addition of 30% sodium hydroxide solution, stirring the reaction, the reaction is over to produce 5-methyltetrazole sodium salt; 3. The 5-methyl tetrazole sodium salt obtained in step (2) is added hydrochloric acid dropwise, stirring reaction, finished adding ethyl acetate extraction, take the oil layer, distillation, centrifugation, drying that is 5-methyl tetrazole boutique; 4. The 5-methyl tetrazole boutique obtained in step (3) is obtained after drying treatment that is 5-methyl tetrazole finished product.