5-Methyl-1H-tetrazole

5-Methyl Tetrazole is used in the preparation of novel antifungal agents based derived from N-iodopropargylazoles and N-triiodoallylazoles. 5-Methyl Tetrazole also in the preparation of novel quinoline derivatives against mycobacterium tuberculosis.

5-methyl-1H-tetrazole (MTZ) is a tetrazolium derivative. MTZ can be used as a starting material for the synthesis of novel energetic salts (including cationic and anionic salts, such as perchlorate, nitrate, guanidine salt, etc.)[1]. It can also form eutectic compounds with 5-Aminotetrazole to improve the combustion performance of pyrotechnic fuels and enhance their moisture resistance[2].

5-Methyl-1H-tetrazole is used in the preparation of novel antifungal agents based derived from N-iodopropargylazoles and N-triiodoallylazoles. 5-Methyl Tetrazole also in the preparation of novel quinoline derivatives against mycobacterium tuberculosis.

5-methyl-1H-tetrazole is a flammable solid. This substance is irritating to humans. Contact may cause skin irritation and severe eye irritation. Inhalation may cause respiratory tract irritation.

[1] Kazuki Inoue. (2024). Synthesis, crystallographic characterization, and thermal analyses of five 5-methyl-1H-tetrazole salts. Science and Technology of Energetic Materials, 85 5, 53-59. https://doi.org/10.34571/stem.85.5_53
[2] Kazuki Inoue, Ken Okada, Shinya Matsumoto, (2025). Enhancing stability of 5-amino-1H-tetrazole against hydration via cocrystallization, Science and Technology of Energetic Materials, 86 1, 19-24. https://doi.org/10.34571/stem.86.1_19