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2',4'-Dihydroxypropiophenone

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2',4'-Dihydroxypropiophenone Basic information
2',4'-Dihydroxypropiophenone Chemical Properties
  • Melting point:95-98 °C(lit.)
  • Boiling point:178 °C / 7mmHg
  • Density 1.1708 (rough estimate)
  • refractive index 1.5260 (estimate)
  • pka8.03±0.40(Predicted)
  • BRN 1238635
  • InChIKeyLLBBBYLDTDJMNU-UHFFFAOYSA-N
  • CAS DataBase Reference5792-36-9(CAS DataBase Reference)
Safety Information
MSDS
2',4'-Dihydroxypropiophenone Usage And Synthesis
  • Chemical Propertieslight yellow crystals or crystalline powder
  • PreparationPreparation by reaction of propionic acid with resorcinol,
    in the presence of zinc chloride (Nencki reaction), at reflux (160–165°) ? for 15 min, at 150° for 20 min
    in the presence of boron trifluoride for 2 h at 70° (79%), at 80° (67%) ? or at 105–108° for 15 min (71%)
    in the presence of polyphosphoric acid for 10–20 min in a boiling water bath ? (65%)
    in the presence of 70% perchloric acid at reflux for 30 min (70%)
    in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid type) ? at 160° for 2–3 h (76%)
    Preparation by reaction of propionitrile with resorcinol (Hoesch reaction) (75%) (65%) (46%)(35%)
    Preparation by reaction of propionic anhydride with resorcinol
    in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid ? type) at 160° for 2–3 h (82%)
    in the presence of concentrated sulfuric acid (small drops) at 130° for some ? min (60%)
    Also obtained by Fries rearrangement of resorcinol dipropionate
    with aluminium chloride at 180–185° for 90 min (25%)
    with boron trifluoride, in the presence of resorcinol, at 75° for 1 h (83%)
    Also obtained by reaction of ethylmagnesium bromide with 2,4-dihydroxy-N, N-diethylbenzamide in refluxing benzene (12%).
2',4'-Dihydroxypropiophenone Preparation Products And Raw materials
2',4'-Dihydroxypropiophenone(5792-36-9)Related Product Information
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