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FASUDIL

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FASUDIL Basic information
FASUDIL Chemical Properties
  • Boiling point:506.2±60.0 °C(Predicted)
  • Density 1.289±0.06 g/cm3(Predicted)
  • storage temp. Store at RT
  • solubility H2O: >200 mg/mL
  • form solid
  • pka9.73±0.20(Predicted)
  • color white
  • Water Solubility Soluble in water or DMSO
  • CAS DataBase Reference103745-39-7(CAS DataBase Reference)
Safety Information
  • WGK Germany 3
  • RTECS HM4031166
  • HS Code 29334900
FASUDIL Usage And Synthesis
  • Chemical PropertiesWhite Crystalline Solid
  • Usesvasodilator (cerebral), Ca antagonist
  • UsesA potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced co ntraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho- associated Kinase (ROCK IC50= 10.7 uM).
  • Biological ActivityCyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.
FASUDIL Preparation Products And Raw materials
FASUDIL(103745-39-7)Related Product Information
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