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FASUDIL

FASUDIL Structure
FASUDIL
  • CAS No.103745-39-7
  • Chemical Name:FASUDIL
  • CBNumber:CB3101698
  • Molecular Formula:C14H17N3O2S
  • Formula Weight:291.37
  • MOL File:103745-39-7.mol
FASUDIL Property
  • Boiling point: :506.2±60.0 °C(Predicted)
  • Density  :1.289±0.06 g/cm3(Predicted)
  • storage temp.  :Store at RT
  • solubility  :H2O: >200 mg/mL
  • form  :solid
  • pka :9.73±0.20(Predicted)
  • color  :white
  • Water Solubility  :Soluble in water or DMSO
  • CAS DataBase Reference :103745-39-7(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :Q0CH43PGXS
Safety
  • WGK Germany  :3
  • RTECS  :HM4031166
  • HS Code  :29334900
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
FASUDIL Price More Price(2)
  • Brand: Sigma-Aldrich
  • Product number: 371970
  • Product name : HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem
  • Purity: 
  • Packaging: 1mg
  • Price: $124
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63525
  • Product name : Fasudil, 98+%
  • Purity: 
  • Packaging: 10mg
  • Price: $203
  • Updated: 2020/06/24
  • Buy: Buy

FASUDIL Chemical Properties,Usage,Production

  • Chemical Properties White Crystalline Solid
  • Uses vasodilator (cerebral), Ca antagonist
  • Uses A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced co ntraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho- associated Kinase (ROCK IC50= 10.7 uM).
  • Biological Activity Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.
FASUDIL Preparation Products And Raw materials
Raw materials
Preparation Products
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103745-39-7, FASUDILRelated Search:
  • Fasudil Hydrochloride Injection
  • 5-(AZEPAN-4-YLSULFONYL)ISOQUINOLINE DIHYDROCHLORIDE
  • Fasudil HCI
  • 5-(1,4-diazepan-4-ium-1-ylsulfonyl)isoquinoline
  • Fasudil Hydrchloride
  • 1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE
  • at877
  • hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine
  • HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE
  • HA 1077, DIHYDROCHLORIDE, 99+%
  • FASUDIL
  • Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
  • 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-
  • Fasudilum
  • Fasudilum [inn-latin]
  • HA-1077:Eril
  • 2,3,4,5,6,7-Hexahydro-1-(isoquinolin-5-ylsulfonyl)-1H-1,4-diazepine
  • 5-(Hexahydro-1H-1,4-diazepine-1-ylsulfonyl)isoquinoline
  • H-1077 dihydrochloride
  • HA-1077 Dihydrochloride Salt >99%
  • 1-(5-Isoquinolinesulfonyl)homopiperazine, Dihydrochloride Salt
  • 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline dihydrochloride
  • 103745-39-7
  • C14H17N3O2S2HCl
  • Signalling
  • Protein Kinase Inhibitors and Activators
  • Protein Kinase
  • Angiogenesis and Metastasis
  • Intracellular signaling
  • ERIL
  • APIs