Ofurace is a systematic fungicide used to control diseases caused by phycomycetes. Ofurace is commonly used in agriculture to control potato late blight.
ChEBI: 2-chloro-N-(2,6-dimethylphenyl)-N-(2-oxotetrahydrofuran-3-yl)acetamide is an aromatic amide that is 2,6-dimethylaniline in which the two amino hydrogens are replaced by chloroacetyl and 2-oxotetrahydrofuran-3-yl groups It is an aromatic amide, an organochlorine compound, a butan-4-olide and a tertiary carboxamide.
The commercial synthesis of ofurace involves constructing its core structure through acylation and lactone coupling reactions. The process begins with 2,6-dimethylaniline, which undergoes chloroacetylation using chloroacetyl chloride to form 2-chloro-N-(2,6-dimethylphenyl)acetamide. This intermediate is then reacted with tetrahydro-2-oxo-3-furanol, a γ-butyrolactone derivative, under controlled conditions to yield the final compound: Ofurace. The reaction typically takes place in an organic solvent like toluene or acetonitrile, with a base such as triethylamine to facilitate nucleophilic substitution.
Systemic with curative and protective action. Disrupts fungal nucleic acid synthesis - RNA ploymerase 1.
