8-Methylquinoline

CAS611-32-5

MFC10H9N

MW143.19

EINECS210-264-0

Chemical Properties

Melting point	-80 °C
Boiling point	245 °C
Density	1.052 g/mL at 25 °C(lit.)
refractive index	n20/D 1.614(lit.)
Flash point	221 °F
storage temp.	Room Temperature
solubility	Chloroform, Methanol
pka	5.03±0.17(Predicted)
form	Liquid
color	Clear yellow
Specific Gravity	1.052
Water Solubility	0.1-0.5 g/100 mL at 17 ºC
BRN	111340
InChIKey	JRLTTZUODKEYDH-UHFFFAOYSA-N
CAS DataBase Reference	611-32-5(CAS DataBase Reference)
NIST Chemistry Reference	Quinoline, 8-methyl-(611-32-5)
EPA Substance Registry System	8-Methylquinoline (611-32-5)

Safety Information

MSDS

Chemical Properties

clear yellow liquid
Uses

8-Methylquinoline is used in QSAR treatment of mutagenicity and cytotoxicity of quinolines.
Uses

8-Methylquinoline has been used in preparation of osmium chloridophosphine complexes, as quinoline carbene tautomers.
Uses

8-Methylquinoline has been used in preparation of osmium chloridophosphine complexes, as quinoline carbene tautomers.Tumorigenic potential of 8-methylquinoline has been evaluated in newborn CD-1 mice and Sprague-Dawley rats.
Definition

ChEBI: A methylquinoline carrying a methyl substituent at position 8.
Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 1514, 1980 DOI: 10.1021/jo01296a035
General Description

Yellow liquid or oil.
Air & Water Reactions

Slightly soluble in water.
Reactivity Profile

8-Methylquinoline may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard

8-Methylquinoline is combustible.
Purification Methods

Purify it as for 2-methylquinoline. The phosphate and picrate have m 158o and m 201o, respectively. [Beilstein 20 III/IV 3500, 20/7 V 405.]