Chemical Properties
clear yellow liquid
Uses
8-Methylquinoline is used in QSAR treatment of mutagenicity and cytotoxicity of quinolines.
Uses
8-Methylquinoline has been used in preparation of osmium chloridophosphine complexes, as quinoline carbene tautomers.Tumorigenic potential of 8-methylquinoline has been evaluated in newborn CD-1 mice and Sprague-Dawley rats.
Definition
ChEBI: A methylquinoline carrying a methyl substituent at position 8.
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 1514, 1980
DOI: 10.1021/jo01296a035
General Description
Yellow liquid or oil.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
8-Methylquinoline may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard
8-Methylquinoline is combustible.
Purification Methods
Purify it as for 2-methylquinoline. The phosphate and picrate have m 158o and m 201o, respectively. [Beilstein 20 III/IV 3500, 20/7 V 405.]
