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Berberine

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Berberine Basic information
Berberine Chemical Properties
  • Melting point:204-206 °C (dec.)
  • Boiling point:486.8°C (rough estimate)
  • Density 1.2976 (rough estimate)
  • refractive index 1.5800 (estimate)
  • pka2.47(at 25℃)
  • color White to yellow crystals
  • Water Solubility 43.48g/L(25 ºC)
  • CAS DataBase Reference2086-83-1(CAS DataBase Reference)
Safety Information
  • RIDADR 1544
  • WGK Germany 2
  • RTECS DR9866400
  • 3-10
  • HazardClass 6.1(b)
  • PackingGroup III
  • ToxicityLD50 orl-mus: 329 mg/kg YKKZAJ 82,726,62
MSDS
Berberine Usage And Synthesis
  • Chemical PropertiesWhite to yellow crystals. Iinsoluble in water; soluble in ether, alcohol. Salts of berberine are berberine bisulfate, berberine sulfate, and berberine hydrochloride. All three are yellow crystals, slightly soluble in water.
  • UsesAntiseptic drug.Treat intestinal infection caused from dysentery bacillus and E.coil
  • brand name3 p maid;Berberal;Berberil;Detal;Kenmin-s;Kinosin s;Phelloverin a;Tangenin;Thalsin.
  • World Health Organization (WHO)Berberine, an alkaloid contained in many plants including Berberis species, remains available in many tropical countries. Both traditional herbal remedies and tablet formulations containing this substance have been used in the treatment of gastrointestinal disease, and injectable preparations have been claimed to be of value in the treatment of cutaneous leishmaniasis. The action taken in Singapore relates to reports of jaundice, haemolytic anaemia and kernicterus with brain damage in infants with G6PD deficiency who were exposed either in utero or post-natally. Preparations for topical application are also available in some countries. These have not been associated with reports of systemic toxicity.
  • HazardToxic via ingestion, inhalation, skin absorption.
  • Safety ProfileAn alkaloid poison by ingestionand subcutaneous routes. In humans, toxic doses lowerthe body temperature, increase peristalsis, and cause deathby central paralysis. Mutation data reported. Should carry apoison label. Should never be ingested without t
  • Purification MethodsBerberine crystallises from pet ether or ether as yellow needles or from H2O. [Beilstein 27 II 567, 27 III/IV 6539.]
Berberine Preparation Products And Raw materials
Berberine(2086-83-1)Related Product Information
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