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Parthenolide

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Parthenolide Basic information
Parthenolide Chemical Properties
  • Melting point:115-116 °C(lit.)
  • alpha D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
  • Boiling point:394.1±42.0 °C(Predicted)
  • Density 1.13±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • form White solid
  • Merck 14,7048
  • CAS DataBase Reference20554-84-1
Safety Information
MSDS
Parthenolide Usage And Synthesis
  • Chemical PropertiesWhite solid
  • UsesAntiinflammatory;MAP kinase inhibitor
  • UsesParthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.
  • DefinitionChEBI: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
  • Biological ActivityThe active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Parthenolide is antisecretory, anti-inflammatory, spasmolytic and inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B 4 and thromboxane B 2 .
  • Contact allergensParthenolide is a sesquiterpene lactone found Asteraceae- Compositae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.).
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