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GANGLIOSIDE GD1A DISODIUM SALT

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GANGLIOSIDE GD1A DISODIUM SALT Basic information
GANGLIOSIDE GD1A DISODIUM SALT Chemical Properties
  • storage temp. -20°C
  • solubility DMSO: soluble
  • form lyophilized powder
  • BRN 6228822
Safety Information
  • Safety Statements 22-24/25
  • WGK Germany 3
  • 10-21
  • HS Code 29400090
MSDS
GANGLIOSIDE GD1A DISODIUM SALT Usage And Synthesis
  • DescriptionGanglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (TLR2), enabling the recruitment of TLR2 to lipid rafts when bound by a bacterial toxin. Ganglioside GD1a mixture contains ganglioside GD1a molecular species with C18:1 and C20:1 sphingoid backbones.
  • Chemical PropertiesWhite powder
  • UsesGanglioside GD1a Disodium Salt is an agent with a stimulatory effect on phagocytosis and phagosome-lysosome.
  • General Description
    Ganglioside GD1a is an anionic brain ganglioside. It is localized in the inner and outer membrane of nuclear envelope of the neuronal cells. GD1a contains a neutral tetrasaccharide core, with one or two sialic acid on the internal galactose. It also has an additional sialic acid on the non-reducing terminal of galactose.
GANGLIOSIDE GD1A DISODIUM SALT(12707-58-3)Related Product Information
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