Metaflumizone is a semicarbazone broad-spectrum insecticide. It has a low aqueous solubility, is non-volatile and a low potential for leaching to groundwater based on its chemical properties. It is persistent in soil and in water-sediment systems. It has a low mammalian toxicity and considered to have potential negative reproduction/developmental effects. It also has a high potential for bioaccumulation. It has a low to moderate toxicity to most birds, aquatic species, honeybees and earthworms.
Cyhalofop-butyl is a white crystalline powder with weak aromatic odor. Cyhalofop-butyl is an aminocarbamate insecticide, low toxicity, environmentally friendly, low value of endosulfan.
Metaflumizone is a semicarbazone insecticide that works by blocking sodium channel in target insects resulting in paralyzation associated with blocking nerve activity. Metaflumizone is useful as a hea rtworm control treatment.
Metaflumizone is synthesised through a condensation reaction involving two key intermediates: m-trifluoromethylphenyl-4-nitrilebenzylketone and p-trifluoromethoxyphenylaminohydrazide. These compounds are combined in a reactor with a water-insoluble organic solvent and a suitable catalyst, then heated to temperatures between 80 DegC and 140 DegC for 1 to 3 hours. During the reaction, water is generated and removed by the solvent, which drives the reaction forward and improves yield. After completion, the mixture is cooled to between 0 and 30 DegC, and the product is isolated by filtration.
Broad-spectrum, attacks insect nervous system causing paralysis. Voltage-dependent sodium channel modulator.
Veterinary Drugs and Treatments
Metaflumizone is a new insecticide used for the treatment and control of fleas on dogs and cats. It blocks the influx of sodium required
to propagate a nerve impulse along the axon and dendrite of the neuron causing a reduction in feeding, loss of coordination, paralysis
and death of the flea.
Insecticide; Veterinary substance
