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Penicillin V potassium salt

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Penicillin V potassium salt Basic information
Penicillin V potassium salt Chemical Properties
  • Melting point:197-202°C
  • alpha D25 +223° (c = 0.2)
  • Density 1.40
  • storage temp. Inert atmosphere,2-8°C
  • solubility Freely soluble in water, practically insoluble in ethanol (96 per cent).
  • form neat
  • color Sol in water
  • Water Solubility Soluble in water, dimethyl sulfoxide, and methanol.
  • BRN 3899451
  • CAS DataBase Reference132-98-9(CAS DataBase Reference)
  • EPA Substance Registry SystemPenicillin V Potassium (132-98-9)
Safety Information
Penicillin V potassium salt Usage And Synthesis
  • Chemical PropertiesCrystalline Solid
  • OriginatorOracilline ,Theraplix ,France ,1954
  • UsesPenicillin V Potassium bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. It inhibits biosynthesis of cell-wall mucopeptide. It is used to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
  • UsesPenicillin antibacterial.
  • Manufacturing ProcessThe following description is taken from US Patent 2,941,995. A solution of phenoxyacetyl chloride (360 mg) in dry acetone (5 ml) was added dropwise during 10 minutes to a stirred solution of 6-aminopenicillanic acid (450 mg, approximately 75% pure) in 3% aqueous bicarbonate (18 ml), and acetone (12 ml). When addition was complete the mixture was stirred at room temperature for 30 minutes and then extracted with ether (30 ml in 3 portions), only the aqueous phase being retained. This aqueous solution was covered with butanol (5 ml) and adjusted to pH 2 by the addition of N hydrochloric acid. After separating the layers, the aqueous phase was extracted with two 2.5 ml portions of butanol, adjusting to pH 2 each time. The combined butanol solutions (which at this stage contained the free penicillanic acid) were washed with water (3 x 2 ml) and then shaken with water (10 ml) to which sufficient 3% sodium bicarbonate solution was added to bring the aqueous phase to pH 7. The butanol solution was further extracted with two 5 ml portions of water to each of which was added enough bicarbonate solution to produce an aqueous phase of pH 7. The combined aqueous solutions were washed with ether (20 ml) and then evaporated at low temperature and pressure to leave the crude sodium salt of phenoxymethyl penicillin which, after drying in a vacuum desiccator, was obtained as a slightly hygroscopic powder (591 mg).
  • brand nameV-Cillin(Lilly).
  • Therapeutic FunctionAntibacterial
  • General DescriptionOdorless white crystalline powder. Slightly bitter taste. pH (0.5% aqueous solution) 5 to 7.5.
  • Air & Water ReactionsWater soluble.
  • Reactivity ProfilePenicillin V potassium salt is the potassium salt of penicillin v. Penicillin V potassium salt is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. Penicillin V potassium salt is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. Penicillin V potassium salt may also be incompatible with naphthalene oils and vitamin B.
  • Fire HazardFlash point data for Penicillin V potassium salt are not available; however, Penicillin V potassium salt is probably combustible.
  • Safety ProfileModerately toxic by ingestion, intramuscular, intraperitoneal, and intravenous routes. Human mutation data reported. Questionable carcinogen with no experimental evidence. When heated to decomposition it emits very toxic fumes of NOx, K2O, and SOx. Used
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