ChemicalBook > Product Catalog > API > Antibiotics > Other antibiotic Drugs > 6-Aminopenicillanic acid
6-Aminopenicillanic acid
- Product Name:6-Aminopenicillanic acid
- CAS:551-16-6
- MF:C8H12N2O3S
- MW:216.26
- EINECS:208-993-4
- Mol File:551-16-6.mol
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6-Aminopenicillanic acid Chemical Properties
- Melting point:198-200 °C (dec.)(lit.)
- alpha 276.3 º (c=1.2, 0.1N HCl 22 ºC)
- Boiling point:460.2±45.0 °C(Predicted)
- Density 1.3418 (rough estimate)
- refractive index 1.6300 (estimate)
- storage temp. 2-8°C
- solubility 2.46g/l
- pkapKa 2.3 (Uncertain)
- form Fine Powder
- color White to cream
- PH3.4 (100g/l, H2O)
- optical activity[α]22/D +276.3°, c = 1.2 in 0.1 M HCl
- Water Solubility Soluble in water and hydrochoric acid.
- Merck 14,458
- BRN 15080
- InChIKeyNGHVIOIJCVXTGV-SDKNWNMFSA-N
- CAS DataBase Reference551-16-6(CAS DataBase Reference)
- EPA Substance Registry System6-Aminopenicillanic acid (551-16-6)
- Hazard Codes Xn
- Risk Statements 42/43
- Safety Statements 22-36/37-45-37-24-36
- WGK Germany 2
- RTECS XH8225000
- F 10
- TSCA Yes
- HS Code 29349990
- Language:EnglishProvider:6-Aminopenicillanic acid
- Language:EnglishProvider:ACROS
- Language:EnglishProvider:SigmaAldrich
- Language:EnglishProvider:ALFA
6-Aminopenicillanic acid Usage And Synthesis
- Chemical PropertiesWHITE TO CREAM FINE POWDER
- Uses(+)-6-Aminopenicillanic Acid is the core structure in penicillins, obtained from the fermentation brew of the Penicillium mold. (+)-6-Aminopenicillanic Acid is used as the main starting block for the preparation of numerous semisynthetic penicillins.
- DefinitionChEBI: A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and ph rmacologic characteristics.
- Safety ProfileQuestionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.
- Purification MethodsThis acid crystallises from water. [Kleppe & Stroninger J Biol Chem 254 4856 1979,Beilstein 27 III/IV 2858.]
6-Aminopenicillanic acid Preparation Products And Raw materials
- Raw materialsAmmonium bicarbonate(2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acidPotassium benzylpenicillinBis(2-dimethylaminoethyl) etherAmpicillin
- Preparation ProductsImipenemPenicillin GPipracilOxacillin sodium monohydrateCARBENICILLIN
- Mecillinam 7-(2,2-DIMETHYL-5-OXO-4-PHENYL-IMIDAZOLIDIN-1-YL)-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID Cloxacillin-13C4 SodiuM Salt Dicloxacillin sodium Mezlocillin Ampicillin Potassium benzylpenicillin 6-Aminopenicillanic acid Acetaminophen Dimethyl sulfoxide 2-(2-Aminothiazol-4-yl)glyoxylic acid N,N-Dimethyl-1,4-phenylenediamine N,N-Dimethylformamide CARBOXYLIC ACID Dimethyl ether Dimethyl fumarate ETHANE EC 2.6.1.2
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