ChemicalBook Product Catalog Organic Chemistry Amides Acyclic polyamines and their derivatives Bis(2-dimethylaminoethyl) ether

Bis(2-dimethylaminoethyl) ether

Product NameBis(2-dimethylaminoethyl) ether
CAS3033-62-3
MFC8H20N2O
MW160.26
EINECS221-220-5
MOL File3033-62-3.mol

Chemical Properties

Boiling point	189 °C/760 mmHg
Density	0.841 g/mL at 25 °C
vapor pressure	49Pa at 20℃
refractive index	n 20/D 1.430
Flash point	151 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in water
form	clear liquid
pka	9.12±0.28(Predicted)
color	Colorless to Light yellow
Water Solubility	100g/L at 20℃
BRN	1739668
Henry's Law Constant	7.9×10¹ mol/(m³Pa) at 25℃, Du et al. (2017)
Exposure limits	ACGIH: TWA 0.05 ppm; STEL 0.15 ppm (Skin)
InChI	1S/C8H20N2O/c1-9(2)5-7-11-8-6-10(3)4/h5-8H2,1-4H3
InChIKey	GTEXIOINCJRBIO-UHFFFAOYSA-N
SMILES	CN(C)CCOCCN(C)C
LogP	-0.34 at 20℃
CAS DataBase Reference	3033-62-3(CAS DataBase Reference)
NIST Chemistry Reference	Ethanamine, 2,2'-oxybis[N,N-dimethyl-(3033-62-3)
EPA Substance Registry System	Bis[2-(dimethylamino)ethyl]ether (3033-62-3)

Safety Information

Hazard Codes	T
Risk Statements	20-22-24-34
Safety Statements	26-36/37/39-45
RIDADR	UN 2927 6.1/PG 2
WGK Germany	2
RTECS	KR9460000
TSCA	TSCA listed
HazardClass	3
PackingGroup	III
HS Code	29221990
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Dam. 1 Skin Corr. 1B
Hazardous Substances Data	3033-62-3(Hazardous Substances Data)
Toxicity	LD50 orl-rat: 1070 mg/kg JTOTDO 5,3,86

MSDS

Provider	Language
Bis(2-dimethylaminoethyl) ether	English
SigmaAldrich	English
ALFA	English

Usage And Synthesis

Chemical Properties

Colorless and transparent liquid or Brown liquid. Soluble in water, easily soluble in alcohol, benzene, etc.

Uses

Bis(2-dimethylaminoethyl) ether is an efficient tertiary amine catalyst, which is suitable for the production of almost all foam products, mainly for the production of flexible foam products, especially for high resilience and RIM products. It is characterized by high catalytic activity, smooth foaming, large tolerance to tin, easy to adjust the formulation, and the physical and chemical properties of products produced with it, such as resilience and elongation, are better than other products.

Preparation

The main methods for the synthesis of Bis(2-dimethylaminoethyl) ether are:
(1) reaction of sodium dimethylaminoethanol and SO3 or chlorosulfonic acid;
(2) Reaction of trimethylamine with dichloroethyl ether or dimethylaminoethoxyethyl ether;
(3) One-step synthesis of dimethylamine and monoethyleneglycol under solid catalyst.

Application

Bis(2-dimethylaminoethyl) Ether (Potassium Clavulanate EP Impurity M) is used in the manufacturing of flexible polyurethane foams.

General Description

Bis(2-(dimethylamino)ethyl)ether appears as a clear or yellow liquid. Bp: 188°C. Toxic by inhalation, by skin absorption, ingestion, and eye contact.

Reactivity Profile

Bis (2-(dimethylamino)ethyl)ether reacts as a base. Reacts exothermically with acids. May form explosive peroxides upon exposure to the air.

Safety Profile

Poison by skin contact.Moderately toxic by ingestion. Experimental reproductiveeffects. A severe skin and eye irritant.

Toxics Screening Level

The initial threshold screening level (ITSL) for bis(2-dimethylaminoethyl)ether is 0.3 μg/m3 (based on an annual averaging time).

Bis(2-dimethylaminoethyl) ether

Chemical Properties

Safety Information

MSDS

Usage And Synthesis

Preparation Products And Raw materials

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