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Isosorbide Basic information
Isosorbide Chemical Properties
  • Melting point:60-63 °C (lit.)
  • Boiling point:175°C/2mmHg(lit.)
  • alpha 42 º (c=3, H2O)
  • Density 1.0945 (rough estimate)
  • refractive index 45 ° (C=5, H2O)
  • storage temp. Refrigerator
  • form Crystals, Crystalline Solid or Mass
  • pka13.17±0.40(Predicted)
  • color Off-white to light yellow or beige
  • optical activity[α]20/D +45.2°, c = 3 in H2O
  • Water Solubility Soluble in alcohols, water and ketones.
  • Sensitive Hygroscopic
  • Merck 14,5224
  • BRN 80510
  • CAS DataBase Reference652-67-5(CAS DataBase Reference)
  • EPA Substance Registry SystemD-Glucitol, 1,4:3,6-dianhydro- (652-67-5)
Safety Information
Isosorbide Usage And Synthesis
  • Chemical Propertiesoff-white to light yellow or beige crystals,
  • UsesIsosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.
  • Usespharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.
  • DefinitionA polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.
  • brand nameIsmotic (Alcon).
  • Biological Functionsemergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.
  • Clinical UseIsosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.
Isosorbide Preparation Products And Raw materials
Isosorbide(652-67-5)Related Product Information
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