5-Fluorothiazol-2-amine hydrochloride

731018-54-5

745053-64-9

b) Synthesis of 5-fluorothiazol-2-amine hydrochloride; N-(5-fluoro-2-thiazolyl)-carbamic acid-1,1-dimethylethyl ester (4.6 g, 21.1 mmol) was dissolved in dioxane (25 mL). HCl gas was passed into the solution for 4 h. Subsequently, ether (50 mL) was added to form a suspension and the solid was collected by filtration. The resulting solid was dried under high vacuum to give 5-fluorothiazol-2-amine hydrochloride (3.03 g, 19.7 mmol, 93% yield). The product was confirmed by 1H NMR (D2O): δ 7.00 (1H, d); mass spectrometry analysis showed m/z = 119.0 [M + H]+.