Auramine is a yellow crystalline powder or
flaky material.
Certified for use by fluorescence microscopy in Churukian's modification of Truant's fluorescent method for acid fast bacilli on paraffin sections.
Fluorescent stain for acid-resistant bacteria in sputum
ChEBI: A hydrochloride obtained by combining 4,4'-carbonimidoylbis(N,N-dimethylaniline) with one molar equivalent of hydrogen chloride. A fluorescent stain for demonstrating acid fast organisms in a method similar to the Zieh
Neelsen. It also can be used to make a fluorescent Schiff reagent.
AURAMINE O is incompatible with strong oxidizing agents.
Flash point data for AURAMINE O are not available. AURAMINE O is probably combustible.
Auramine O is used for the staining of acid-fast organisms, coccidia. Auramine O along with carbol generates brilliant yellow fluorochrome of tubercle bacilli. It is effective in detecting positive cases of tuberculosis. Auramine O binds to the mycolic acid in the bacterial cell wall.
Auramine is used industrially as a dye
or dye intermediate for coloring textiles; paper, and leather.
Also used as an antiseptic (a powerful antiseptic in ear and
nose surgery, and treatment of gonorrhea) and fungicide.
Human exposure to auramine occurs principally through
skin absorption or inhalation of vapors. Low-level dermal
exposure to the consumer may occur but would be limited
to any migration of auramine from fabric, leather, or paper
goods.
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye
intermediates, solid, toxic, n.o.s., Hazard Class: 6.1;
Labels: 6.1-Poisonous materials, Technical Name Required.
Properties and Applications
|
TEST ITEMS
|
SPECIFICATION
|
|
APPEARANCE
|
DARK YELLOWPOWDER
|
|
SHADE
|
BRIGHT YELLOWISH
|
|
HEAT RESISTANCE
|
280 °C min
|
|
DENSITY
|
1.07 g/cm
3
|
|
WATER FASTNESS
|
4-5
|
|
LIGHT FASTNESS
|
1-2
|
|
BLEACHABILITY (OXIDATIVE)
|
4
|
|
BLEACHABILITY (REDUCTIVE)
|
3
|
|
WATER SOLUBILITY AT
20
°C
|
10 g/L min
|
|
WATER INSOLUBLE
|
1.0% max
|
|
MOISTURE
|
3.0% max
|
|
TINTING STRENGTH
|
100-105 %
|
|
WEIGHT METAL TOTAL
|
50ppm max
|
It crystallises from EtOH as the hydrochloride and is very slightly soluble in CHCl3, UV: 434nm ( 370). The free base (carbinolamine) has m 136o (from *C6H6). [Goldacre & Phillips J Chem Soc 1724 1949, Conrad et al. Biochemistry 9 1540 1970, Beilstein 14 IV 256.]
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides.
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Incinerate in furnace with afterburner and scrubber.
