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Paricalcitol Basic information
Paricalcitol Chemical Properties
  • Boiling point:564.8±50.0 °C(Predicted)
  • Density 1.121±0.06 g/cm3(Predicted)
  • Flash point:14℃
  • pka14.34±0.40(Predicted)
  • form neat
  • CAS DataBase Reference131918-61-1(CAS DataBase Reference)
Safety Information
Paricalcitol Usage And Synthesis
  • DescriptionParicalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.
  • Chemical PropertiesWhite Solid
  • OriginatorAbbott (US)
  • UsesSynthetic analog of vitamin D. Antihyperparathyroid.
  • UsesAntihyperparathyriod
  • Uses1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
  • brand nameZemplar (Abbott).
Paricalcitol(131918-61-1)Related Product Information
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