ChemicalBook > Product Catalog > Analytical Chemistry > Standard > Pharmaceutical Impurity Reference Standards > Paricalcitol
Paricalcitol
- Product Name:Paricalcitol
- CAS:131918-61-1
- MF:C27H44O3
- MW:416.64
- EINECS:658-064-6
- Mol File:131918-61-1.mol
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Paricalcitol Chemical Properties
- Boiling point:564.8±50.0 °C(Predicted)
- Density 1.121±0.06 g/cm3(Predicted)
- Flash point:14℃
- pka14.34±0.40(Predicted)
- form neat
- InChIKeyBPKAHTKRCLCHEA-UBFJEZKGSA-N
- CAS DataBase Reference131918-61-1(CAS DataBase Reference)
- RIDADR UN1170 - class 3 - PG 2 - Ethanol, solution
- HS Code 2936299055
- Hazardous Substances Data131918-61-1(Hazardous Substances Data)
Paricalcitol Usage And Synthesis
- DescriptionParicalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.
- Chemical PropertiesWhite Solid
- OriginatorAbbott (US)
- UsesSynthetic analog of vitamin D. Antihyperparathyroid.
- UsesAntihyperparathyriod
- Uses1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
- brand nameZemplar (Abbott).
- Matrine Zoledronic acid Argatroban 2-((3R,5R)-3,5-bis(tert-butyldiMethylsilyloxy)cyclohexylidene)ethanol (((1R,3R)-5-(2-chloroethylidene)cyclohexane-1,3-diyl)bis(oxy)) bis(tert-butyldimethylsilane) tert-butyl(((1R,3aR,7aR)-1-((2R,5S,E)-5,6-dimethyl -6-((tetrahydro-2H-pyran-2-yl)oxy)hept-3-en-2-yl) -7a-methyloctahydro-1H-inden-4-yl)oxy)dimethylsilane Calcium dobesilate Entacapone Emtricitabine Sofosbuvir Sevelamer hydrochloride (R)-(3-hydroxy-2,3-diMethylbutyl)triphenylphosphoniuM iodide Vitamin D2 Calcifediol Monohydrate Secalciferol Paricalcitol Solution Paricalcitol 1(ALPHA) 25-DIHYDROXYVITAMIN D2*
ParicalcitolSupplierMore
- Company Name:Beijing Honghuixin Medical Technology Co.,Ltd. Gold
- Tel:0101-80456172-
- Email:haiquan.guan@honghui-meditech.com
- Company Name:Pure Chemistry Scientific Inc. Gold
- Tel:001-857-928-2050 or 1-888-588-9418
- Email:sales@chemreagents.com
- Company Name:Conier Chem & Pharma Co.,Ltd, Gold
- Tel:86-023-62922305
- Email:sales@conier.com
- Company Name:Hydragon Pharma Ltd Gold
- Tel: 021-50215258-
- Email:market@hypharma.com;market@hypharma.com
- Company Name:PharmaSea Pharmaceutical Tech. Gold
- Tel:010-52980412
- Email:chemsales@pharmasea.com.cn