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Calcium dobesilate

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Calcium dobesilate Basic information
Calcium dobesilate Chemical Properties
  • Melting point:>300° (dec)
  • storage temp. room temp
  • solubility H2O: soluble15mg/mL, clear
  • form powder
  • color white to beige
  • CAS DataBase Reference20123-80-2(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26
  • WGK Germany 3
  • HazardClass IRRITANT
  • ToxicityLD50 in mice: 700 mg/kg (Esteve-Subirana)
Calcium dobesilate Usage And Synthesis
  • Chemical PropertiesWhite or almost white, hygroscopic powder.
  • OriginatorDoxium,Carrion,France,1971
  • UsesVasotropic/ Venous Disorders
  • Manufacturing ProcessTo an ether solution of 108 grams 1,4-benzoquinone, maintained below 0°C, one adds an also very cold solution of 102 grams of pure calcium bisulfite as a 50% solution in distilled water. The addition is made carefully so as to maintain a very low temperature (0° to 4°C) in the vessel, and under stirring so as to mix the water and ether phase.
    At the end of the addition, an almost colorless ether layer swims on the surface of the strongly colored water layer. After removal of the ether layer, the water layer is concentrated to dryness under vacuum and a stream of an inert gas. An earthy precipitate is formed, which after recrystallization yields 100 grams of hydroquinone calcium sulfonate, which decomposes without melting above 250°C.
    The product consists of very small crystals having a powdery aspect and a pink color which deepens on contact with air. This product is very soluble in water and alcohol, and insoluble in ether.
  • Therapeutic FunctionVasodilator
Calcium dobesilate(20123-80-2)Related Product Information
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