没食子酸甲酯
没食子酸甲酯 性质
| 熔点 | 201-204 °C |
|---|---|
| 沸点 | 278.08°C (rough estimate) |
| 密度 | 1.3840 (rough estimate) |
| 折射率 | 1.5690 (estimate) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 乙醇：50 mg/mL，澄清 |
| 酸度系数(pKa) | 8.04±0.23(Predicted) |
| 形态 | 结晶粉末 |
| 颜色 | 白色至略带米色 |
| 水溶解性 | SOLUBLE IN HOT WATER |
| Merck | 14,4345 |
| BRN | 2113180 |
| InChIKey | FBSFWRHWHYMIOG-UHFFFAOYSA-N |
| LogP | 0.860 |
| CAS 数据库 | 99-24-1(CAS DataBase Reference) |
| EPA化学物质信息 | Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1) |
没食子酸甲酯 用途与合成方法
没食子酸甲酯通过抑制CD4+CD25+调节性T细胞的浸润表现出强大的抗肿瘤活性。
Methyl gallate是具有抗氧化，抗癌和抗炎活性的植物酚类。Methyl gallate也可抑制细菌活性。Methyl gallate 还具有抗 HIV-1 和 HIV-1 酶的抑制活性。Bacterial
The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H 2 O 2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H 2 O 2 (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.
安全信息
| 危险品标志 | Xn,Xi |
|---|---|
| 危险类别码 | 22-36/37/38-43 |
| 安全说明 | 26-36/37-24/25 |
| WGK Germany | 3 |
| RTECS号 | LW8000000 |
| TSCA | Yes |
| 海关编码 | 29182900 |
MSDS信息
没食子酸甲酯 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | L05926 | 3,4,5-三羟基苯甲酸甲酯, 98% | 99-24-1 | 50g | 481 |
| 2024-11-08 | L05926 | 3,4,5-三羟基苯甲酸甲酯, 98% | 99-24-1 | 250g | 1476 |
