没食子酸甲酯

试剂用途生物活性靶点体外研究没食子酸甲酯试剂级价格

没食子酸甲酯

CAS号:99-24-1
英文名:Methyl gallate
中文名:没食子酸甲酯
CBNumber:CB0265566
分子式:C8H8O5
分子量:184.15
MOL File:99-24-1.mol

没食子酸甲酯化学性质

熔点 :201-204 °C
沸点 :278.08°C (rough estimate)
密度 :1.3840 (rough estimate)
折射率 :1.5690 (estimate)
储存条件 :Inert atmosphere,Room Temperature
溶解度 :ethanol: 50 mg/mL, clear
形态 :Crystalline Powder
酸度系数(pKa) :8.04±0.23(Predicted)
颜色 :White to slightly beige
水溶解性 :SOLUBLE IN HOT WATER
Merck :14,4345
BRN :2113180
InChIKey :FBSFWRHWHYMIOG-UHFFFAOYSA-N
LogP :0.860
CAS 数据库 :99-24-1(CAS DataBase Reference)
EPA化学物质信息 :Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)

安全信息

危险品标志 :Xn,Xi
危险类别码 :22-36/37/38-43
安全说明 :26-36/37-24/25
WGK Germany :3
RTECS号 :LW8000000
TSCA :Yes
海关编码 :29182900

没食子酸甲酯 MSDS

Methyl gallate

没食子酸甲酯性质、用途与生产工艺

试剂用途
没食子酸甲酯通过抑制CD4+CD25+调节性T细胞的浸润表现出强大的抗肿瘤活性。
生物活性 Methyl gallate是具有抗氧化，抗癌和抗炎活性的植物酚类。Methyl gallate也可抑制细菌活性。Methyl gallate 还具有抗 HIV-1 和 HIV-1 酶的抑制活性。
靶点

Bacterial
体外研究

The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H ₂ O ₂ treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H ₂ O ₂ (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.
化学性质单斜棱状结晶（甲醇）。熔点为201-203℃（157℃，水合物或溶剂化的结晶）。溶于热水、乙醇、乙醚。
用途联苯双酯的中间体。也是橡胶防老剂。
用途用作联苯双酚和其他药物的中间体
生产方法用没食子酸与甲醇在硫酸催化下酯化制得。