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Serotonin hydrochloride

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Serotonin hydrochloride Basic information
Serotonin hydrochloride Chemical Properties
  • Melting point:149-154 °C(lit.)
  • storage temp. 2-8°C
  • solubility H2O: 17 mg/mL
  • form powder
  • color white to off-white
  • Water Solubility soluble
  • Sensitive Light Sensitive & Hygroscopic
  • Merck 14,8462
  • BRN 3570963
  • Stability:Stable, but light sensitive and hygroscopic. Incompatible with strong oxidizing agents.
  • InChIKeyMDIGAZPGKJFIAH-UHFFFAOYSA-N
  • CAS DataBase Reference153-98-0(CAS DataBase Reference)
Safety Information
MSDS
Serotonin hydrochloride Usage And Synthesis
  • Chemical Propertieswhite to cream powder
  • UsesA neurotransmitter.
  • UsesNeurotransmitter;5-HT agonist
  • UsesSerotonin is a monoamine neurotransmitter.
  • UsesSerotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the gastrointestinal tract. Serotonin is important in the regulation of mood, sleep, vomiting, sexuality, and appetite. Low levels of serotonin are associated with several disorders, including depression, migraines, bipolar disorder, and anxiety. Its actions are terminated primarily via uptake of serotonin from the synapse. Serotonin reuptake can be inhibited with MDMA, cocaine, tricyclic antidepressants, and selective serotonin reuptake inhibitors.[Cayman Chemical]
  • Biological ActivityEndogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo .
  • Purification Methods5-HT is purified by recrystallisation from EtOH/Et2O or Et2O to give the hygroscopic salt. Store it in the dark as it is light sensitive. The free base has m 84-86o (from Et2O). The 5-benzyloxy derivative has m 84-86o (from Et2O). [Ek & Witkop J Am Chem Soc 76 5579 1954, Hamlin & Fischer J Am Chem Soc 73 5007 1951.] The picrate 1H2O has m 196-197.5o (dec with sintering at 160-165o) after crystallisation from Et2O. Serotonin is a natural neurotransmitter [Chuang Life Sci 41 1051 1987]. [Beilstein 22/12 V 16.]
Serotonin hydrochloride Preparation Products And Raw materials
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