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5-Hydroxyindole

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5-Hydroxyindole Basic information
5-Hydroxyindole Chemical Properties
  • Melting point:106-108 °C(lit.)
  • Boiling point:245.66°C (rough estimate)
  • Density 1.1475 (rough estimate)
  • refractive index 1.5260 (estimate)
  • storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
  • solubility 38g/l
  • form Crystalline Needles or Powder
  • pka9.98±0.40(Predicted)
  • color beige
  • Sensitive Light Sensitive
  • BRN 112349
  • CAS DataBase Reference1953-54-4(CAS DataBase Reference)
  • NIST Chemistry ReferenceIndol-5-ol(1953-54-4)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36-37/39
  • WGK Germany 3
  • RTECS NM2430000
  • HazardClass IRRITANT, KEEP COLD
  • HS Code 29339990
MSDS
5-Hydroxyindole Usage And Synthesis
  • Chemical Propertiesbeige to brown crystalline needles or powder
  • Uses• ;Reactant for preparation of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates as antitumor agents and tubulin inhibitors1• ;Reactant for preparation of anthranilic acids2• ;Reactant for preparation of indole compounds as dopamine D2 receptor antagonists3• ;Reactant for preparation of naphthalimide- or carbazole-containing human β-adrenoceptor ligands4• ;Reactant for preparation of melanins as nature-inspired radioprotectors5• ;Reactant for preparation of 5-vinyl-3-pyridinecarbonitriles as PKCθ inhibitors6
  • Uses5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptop han (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets.
  • Synthesis Reference(s)Journal of the American Chemical Society, 76, p. 5579, 1954 DOI: 10.1021/ja01651a001
    The Journal of Organic Chemistry, 49, p. 4833, 1984 DOI: 10.1021/jo00199a017
5-Hydroxyindole Preparation Products And Raw materials
5-Hydroxyindole(1953-54-4)Related Product Information
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