6-Chloromelatonin is a potent agonist of the melatonin receptors.
ChEBI: N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide is a member of acetamides.
Potent melatonin agonist (pK i values are 9.10 and 9.77 for human recombinant MT 1 and MT 2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.
Rats injected with the melatonin agonist, 6-chloromelatonin (0.5 mg/kg) on the day after the phase shift has markedly higher excretion rates of 6-sulphatoxymelatonin compared to those of the controls[5].
MT1: 8.9 (pKi); MT2: 9.1 (pKi)
