Rutaecarpine
- Product Name:Rutaecarpine
- CAS:84-26-4
- MF:C18H13N3O
- MW:287.32
- EINECS:635-907-6
- Mol File:84-26-4.mol
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Rutaecarpine Chemical Properties
- Melting point:259.5-260°
- Boiling point:429.62°C (rough estimate)
- Density 1.2030 (rough estimate)
- refractive index 1.5855 (estimate)
- storage temp. Sealed in dry,2-8°C
- solubility DMSO: 18 mg/mL clear yellow solution, soluble
- form solid
- pka15.79±0.20(Predicted)
- color white
- Merck 14,8298
- InChIKeyACVGWSKVRYFWRP-UHFFFAOYSA-N
- CAS DataBase Reference84-26-4(CAS DataBase Reference)
- Hazard Codes T
- Risk Statements 25-36/37/38
- Safety Statements 45-36-26
- RIDADR UN 2811 6.1/PG 3
- WGK Germany 3
- RTECS NM3454000
- HS Code 29339900
- Language:EnglishProvider:Rutaecarpine
- Language:EnglishProvider:SigmaAldrich
Rutaecarpine Usage And Synthesis
- DescriptionThis alkaloid occurs with Evodiamine (q.v.) in the Chinese drug 'Wou-chou-yu'
which is the dried fruit of Evodia rutaecarpa Benth. It crystallizes from boiling
EtOH as colourless, or pale yellow, needles and is optically inactive. The acetyl
derivative has m.p. 184-6°C and the benzoyl compound, m.p. 194°C. The
alkaloid gives a yellow colour with concentrated H2S04 and is decomposed by
KOH in boiling amyl alcohol yielding anthranilic acid and 3-{3-aminoethylindole-
2-O!carboxylic acid, CllH120 2N2, silky crystals, m.p. 257°C.
Pharmacologically, the alkaloid causes increased arterial pressure on injection. - Chemical PropertiesSolid
- ReferencesAsahina, Kashiwagi., J. Pharm. Chim., 14,54 (1916)
Asahina, Mayeda.,J. Pharm. Soc., Japan, No. 416 (1916)
Asahina, Fujita., ibid, 863 (1921)
Kermack, Perkin, Robinson.,J. Chem. Soc., 119,1615 (1921)
Asahina, Manske, Robinson., ibid, 1708 (1927)
Asahina, Irie, Ohta., J. Pharm. Soc., Japan, 48, 51 (1928)
Ohta., ibid, 60, 109 (1940)
Schopf, Steuer., Annalen, 558, 124 (1947)
Biosynthesis:
Yamazaki, Ikuta., Tetrahedron Lett., 3221 (1966)
Yamazakietal., ibid, 3317 (1967)
Pharmacology:
Raymond-Hamet., Cornpt. rend., 220, 749 (1945)
- Evodiamine CASTICIN Stigmasterol Apigenin Schisandrin WUWEIZISU C CROCIN 1-[(2E,4E,6E,8E,10E,12E,14E)-b-D-glucopyranosyl 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 6-O-b-D-glucopyranosyl-b-D-Glucopyranose 2α,19α－Dihydroxyursolic acid 6-(2-O-alpha-L-Arabinopyranosyl-beta-D-glucopyranosyl)-2-[4-(beta-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one schisanhenol KU-55933 (ATM Kinase Inhibitor) Rutin Gefitinib Rapamycin Rutaecarpine Rutaecarpine Hydroxyevodiamine
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