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Sitagliptin

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Sitagliptin Basic information
Sitagliptin Chemical Properties
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Sitagliptin Usage And Synthesis
  • DescriptionSitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.
  • OriginatorMerck (US)
  • UsesLabeled Sitagliptin , intended for use as an internal standard for the quantification of Sitagliptin by GC- or LC-mass spectrometry.
  • DefinitionChEBI: A triazolopyrazine that exhibits hypoglycemic activity.
  • brand nameJanuvia
Sitagliptin(486460-32-6)Related Product Information
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