Description: Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an Ic50 of 19 nM in Caco-2 cell extractsSitagliptin is believed to exert its actions in patients with type 2 diabetes melitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases qlucagon levels inthe circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for Dpp-4 and does not inhibit DPp-8 orDPp-9 activity in vitro at concentrations approximating those from therapeutic doses.
Synonym: Sitagliptin; LEZ 763; LEZ-763; LEZ763; MK0431; MK 0431; MK-0431;IUPAC/chemical Name: (R)-3-amino-1-(3-(trifluoromethyl)-5,6- dihydro-[1,2,4]triazolof4,3-alpyrazin-7(8H)-yl)-4-(2,4, 5-trifluo
rophenyl)butan-1-oneInchi
Key:MFFMDFFZMYYVKSSECBINFHSA-NInchi code: Inchl=1S/C16H15F6N50/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
SMILES Code: FC(C1=NN=C2CN(C(C[C@H](N)CC3=CC(F)=C(F)C=C3F)=0)CCN21)(F)
FAppearance: Solid powder
Purity:>98% (or refer to the Certificate of Analysis)
Shipping Condition: shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMso
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
China
