Loperamide Hcl

Loperamide Hcl is used to treat sudden diarrhea (including traveler's diarrhea). It works by slowing down the movement of the gut. This decreases the number of bowel movements and makes the stool less watery. Loperamide is also used to reduce the amount of discharge in patients who have undergone an ileostomy. It is also used to treat on-going diarrhea in people with inflammatory bowel disease.Loperamide treats only the symptoms, not the cause of the diarrhea (such as infection).

High affinity μ -opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ -, δ - and κ -opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca²⁺ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca²⁺ channels and at higher concentrations it reduces Ca²⁺ flux through NMDA receptor operated channels.

diarrhea that is watery or bloody,

stomach pain or bloating,

ongoing or worsening diarrhea,

fast or pounding heartbeats,

fluttering in your chest,

shortness of breath, and

lightheadedness