Dibasic Sodium Phosphate

Product NameDibasic Sodium Phosphate
CAS10028-24-7
MF2Na.HO4P.2H2O
MW177.99
EINECS600-053-5
MOL File10028-24-7.mol

Chemical Properties

Melting point	92,5°C
bulk density	850-1000kg/m3
Density	1.064 g/mL at 20 °C
vapor density	4.9 (vs air)
storage temp.	Store at +5°C to +30°C.
solubility	H₂O: 0.5 M at 20 °C, clear, colorless
form	powder
color	White
PH	8.9-9.2 (25℃, 0.5M in H2O)
Odor	Odorless
PH Range	9.1
Water Solubility	Soluble in water
λmax	λ: 260 nm Amax: 0.03 λ: 280 nm Amax: 0.03
Stability	Stable. Incompatible with strong oxidizing agents.
InChI	1S/2Na.H3O4P.2H2O/c;;1-5(2,3)4;;/h;;(H3,1,2,3,4);21H2/q2+1;;;/p-2
InChIKey	KDQPSPMLNJTZAL-UHFFFAOYSA-L
SMILES	O.O.[Na+].[Na+].OP([O-])([O-])=O
CAS DataBase Reference	10028-24-7(CAS DataBase Reference)
EPA Substance Registry System	Disodium phosphate dihydrate (10028-24-7)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25-22
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS	WC4500000
F	3
HS Code	28352200
Storage Class	13 - Non Combustible Solids
Toxicity	LD50 orally in Rabbit: > 2000 mg/kg

MSDS

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

Usage And Synthesis

Chemical Properties

Anhydrous Dibasic sodium phosphate occurs as a white powder. The dihydrate occurs as white or almost white, odorless crystals.

The heptahydrate occurs as colorless crystals or as a white granular or caked salt that effloresces in warm, dry air. The dodecahydrate occurs as strongly efflorescent, colorless or transparent crystals.

Uses

Dibasic sodium phosphate is used in conjunction with trisodium phosphate in foods and water softening treatment. In foods, it is used to adjust pH. Its presence prevents coagulation in the preparation of condensed milk. Similarly, it is used as an anti-caking additive in powdered products.

Preparation

Dibasic sodium phosphate can be generated by neutralization of phosphoric acid with sodium hydroxide:

H3PO4 + 2 NaOH → Na2HPO4 + 2 H2O

Biochem/physiol Actions

Dibasic Sodium Phosphate dehydrate is an important component of running buffer of denaturing gel electrophoresis.

Side effects

Gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of dibasic sodium phosphate as an excipient in oral formulations. However, the level of dibasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.

Metabolism

Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces.