Cefoperazone sodium

한글명:Cefoperazone sodium

카스 번호62893-20-3

상품명:Cefoperazone sodium

CBNumberCB5448988

분자식C25H28N9NaO8S2

포뮬러 무게669.66

MOL 파일62893-20-3.mol

화학적 성질

녹는점	200-202°C
저장 조건	Inert atmosphere,2-8°C
용해도	H₂O: 50 mg/mL, 투명, 희미한 노란색
물리적 상태	가루
색상	흰색에서 황백색까지
수용성	물에 용해됩니다. 알코올에 약간 용해됩니다.
Merck	13,1943
BRN	4902135
안정성	흡습성
InChIKey	NCFTXMQPRQZFMZ-WERGMSTESA-M
SMILES	C(C1=C(CS[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)NC(N3CCN(CC)C(=O)C3=O)=O)C(=O)N12)CSC1=NN=NN1C)(=O)O.[NaH] \|&1:5,7,11,r\|
CAS 데이터베이스	62893-20-3(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	42/43
안전지침서	22-36/37
WGK 독일	2
RTECS 번호	XI0374000
HS 번호	29419000

그림문자(GHS)

Cefoperazone sodium 화학적 특성, 용도, 생산

개요
Cefoperazone was synthesized by Toyama Chemicals Co. in 1978. Except for the hydroxyl group, the side chain attached to the cephem nucleus is the same as that of piperacillin. Cefoperazone shows excellent activity against gram-positive (except Staphylococcus) and gram- negative bacteria, including Pseudomonas aeruginosa. Its pharmacological characteristics are unique. Cefoperazone is excreted mainly in bile, and a concentration five to tenfold higher in bile than in serum is obtained. The transfer into cerebrospinal fluid is 10 – 30 % of the serum concentration; the half-life in serum is 2.0 – 2.6h, and the degree of binding with serum protein is as high as 86.6 %.
화학적 성질
Faint beige powder
용도
For studying the expression, binding, and inhibition of penicillin-binding proteins.Cefoperazone sodium salt is used in the study of drug-protein binding, expression and inhibition of penicillin-binding proteins during cell wall synthesis. It is as an antibacterial and antimicrobial agent useful for prevention of postoperative infection. It is used as an inhibitor of inactivation of alfa-antitrypsin.
Clinical Use
Cefoperazone sodium is a third-generation, antipseudomonalcephalosporin that resembles piperacillinchemically and microbiologically. It is active against manystrains of P. aeruginosa, indole-positive Proteus spp.,Enterobacter spp., and S. marcescens that are resistant tocefamandole. It is less active than cephalothin againstGram-positive bacteria and less active than cefamandoleagainst most of the Enterobacteriaceae. Like piperacillin,cefoperazone is hydrolyzed by many of the β-lactamasesthat hydrolyze penicillins. Unlike piperacillin, however, itis resistant to some (but not all) of the β-lactamases thathydrolyze cephalosporins.Cefoperazone is excreted primarily in the bile. Hepaticdysfunction can affect its clearance from the body.

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