플루바스타틴나트륨염

한글명:플루바스타틴나트륨염

카스 번호93957-55-2

상품명:Fluvastatin sodium salt

CBNumberCB0231286

분자식C24H25FNNaO4

포뮬러 무게433.45

MOL 파일93957-55-2.mol

동의어(한글)

플루바스타틴나트륨염

화학적 성질

녹는점	194-197°C
저장 조건	2-8°C
용해도	H2O: ≥9mg/mL
물리적 상태	가루
색상	흰색에서 황갈색까지
Merck	14,4218
안정성	제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 증류수에 용해된 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
InChIKey	ZGGHKIMDNBDHJB-RPQBTBOMSA-M
CAS 데이터베이스	93957-55-2(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

RTECS 번호

MJ9675050

HS 번호

2933995300

NFPA 704:

	0
2		0

그림문자(GHS)

플루바스타틴나트륨염 화학적 특성, 용도, 생산

개요
Fluvastatin sodium is the fourth HMG-CoA reductase inhibitor to reach the market as a dietary adjunct for lowing total and low-density lipoprotein (LDL) cholesterol. Fluvastatin sodium is the first totally synthetic inhibitor of its class and has more potent effects on reducing serum total and LDL cholesterol and serum triglyceride levels than compactin or lovastatin. Moreover, fluvastatin exhibits a unique set of pharmacological properties including a biopharmaceutical profile most consistent with hepatoselectivity. It has been reported to be well tolerated and to exhibit a safety profile superior to other agents of its class. The main mechanism by which HMG-CoA reductase inhibitors lower plasma cholesterol has been suggested to be up-regulation of hepatocellular LDL-receptor expression and enhancement of receptor-mediated clearance and catabolism of LDL cholesterol.
화학적 성질
Yellow Powder
용도
Fluvastatin-d6 Sodium Salt is the labeled analogue of Fluvastatin Sodium Salt (F601250), a synthetic HMG-CoA reductase inhibitor. Antilipemic.
일반 설명
Fluvastatin sodium is a lipid-lowering drug that belongs to the group of compounds known as statins. It acts by inhibiting the enzyme HMG-CoA reductase that plays a key role in the cholesterol production. It is generally used to reduce plasma cholesterol levels and prevent cardiovascular disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
생물학적 활성
Orally active, potent and competitive HMG-CoA reductase inhibitor (IC 50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC 50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo .

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