クルクミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

  H319：強い眼刺激

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P233：容器を密閉しておくこと。

  P240：容器を接地すること/アースをとること。

  P241：防爆型の電気機器/換気装置/照明機器/．．．機器を使 用すること。

  P242：火花を発生させない工具を使用すること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

クルクミン 価格

MSDS Information

• C.I. 75300

クルクミン 化学特性,用途語,生産方法

• 外観

  黄色～だいだい色の結晶性の粉末

• 定義

  本品は、ウコン Curcuma longa の根から抽出された成分であり、次の化学式で表される。

• 溶解性

  水に難溶。エタノールに微溶。エタノールに溶けにくく、ジエチルエーテルに極めて溶けにくく、水にほとんど溶けない。

• 解説

  ショウガ科ウコンCurcuma longa L.の根茎の色素．クルクミン，橙黄色の結晶性粉末．融点183 ℃．水，エーテルに不溶，エタノール，氷酢酸に可溶．アルカリに濃赤褐色に溶け，酸性にすると淡黄色となる．

  森北出版「化学辞典（第2版）
  

• 用途

  ほう素の定性及び定量用。

• 応用

  古来，絹また綿布の黄色染料として用いられ，また，カレー粉，沢庵(たくあん)漬の着色料としても重要である．ホウ酸塩の検出用試薬紙クルクマ紙(pH 域8～9)は，根茎のアルコール抽出液で沪紙を染めたものである．また，弱アルカリ性で水酸化ベリリウム，水酸化マグネシウムに吸着されて，黄赤色を呈することから，これらの物質の分析にも用いられる．

• 化粧品の成分用途

  酸化防止剤、香料

• 使用上の注意

  不活性ガス封入

• 説明

  The main source of curcumin is the root of Zingiberaceae Curcuma aromatica, rhizome of Curcuma longa (Jiang Huang), Curcuma zedoaria, and Acorus calamus. Among them, Jiang Huang contains about 3–6% curcumin. The traditional Chinese medicine, Jiang Huang, is the root tuber of perennial herbaceous plant Curcuma longa L. of family Zingiberaceae. It was firstly recorded in the “Tang materia medica” (Xin Xiu Ben Cao). It is pungent, bitter, and warm and enters the liver and spleen meridians. It activates the blood, moves qi, dredges meridians, and alleviates pain. In India and other Asian countries, Jiang Huang has more than 6000?years of application history. In Japan, Jiang Huang has a long history of health care, and the people of Okinawa Island regarded Jiang Huang as a holy tribute to the emperor. Jiang Huang mainly comes from Taiwan, Fujian, Guangdong, Guangxi, Yunnan, and Tibet of China and other regions in East Asia and Southeast Asia. It grows in warm and humid climate and sunny environment with abundant rainfall and fears cold frost, drought, and flood. At present, Chinese Pharmacopoeia only included Jiang Huang and Yu Jin which contains curcumin, while curcumin is not included.

• 化学的特性

  orange crystalline powder

• 物理的性質

  Appearance: orange-brown crystalline powder and tastes a little bitter. It will turn into reddish brown in alkaline solution and yellow in neutral and acidic solution. It has strong stability against the reducing agent. It has excellent pigmentation which is not easy to fade. It is sensitive to light, heat, and iron ion. When PH is greater than 8, curcumin turns from yellow to red, which can be used as a pH indicator.
  Solubility: insoluble in water or diethyl ether and soluble in ethanol, propylene glycol, acetic acid, and alkali solution.
  Melting point: about 183 °C.

• 使用

  Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. Curcumin can exist in at least two t

• 定義

  ChEBI: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.

• 一般的な説明

  Orange-yellow needles.

• 空気と水の反応

  Slightly soluble in hot water .

• 反応プロフィール

  Curcumin is sensitive to light and changes in pH. Curcumin may react with oxidizing materials.

• 生物活性

  Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNF α , IL-1, IL-6, PKC, EGFR, NF- κ B, I κ B kinase and more. Upregulates expression of PPAR γ , p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo .

• 作用機序

  Curcumin, the active component of turmeric (Curcuma longa), has been regarded as an anti-inflammatory and antioxidant agent . Particularly, it can scavenge reactive oxygen species, such as hydroxyl radicals, superoxide anion radicals, and nitrogen dioxide radicals. Additionally, it serves as an anti-inflammatory by down-regulating the production of pro-inflammatory cytokines (e.g., IL-1 and TNF-α) and inhibiting the activation of specific transcription factors (e.g., NF-κB and AP-1). Curcumin also demonstrates antiproliferative properties. Specifically, it inhibits UV radiation-induced skin cancer in SKH-1 hairless mice and reduces UVB-induced matrix metalloproteinase-1/3 expression in human dermal fibroblasts via MAPK-p38/JNK pathway suppression.

• 臨床応用

  1. Cholagogic effect could promote bile formation and secretion.
  2. Hypolipidemic effect could reduce the level of cholesterol in the blood and prevent atherosclerosis.
  3. Antibacterial and antiviral effect could inhibit Staphylococcus aureus and HIV.
  4. Liver protection.
  5. Anticancer and antitumor effect.
  6. Help with the prevention of dementia.
  7. Anti-inflammation and treatment of acne and dermatitis.
  8. There are no reports of adverse effect of curcumin till now.

• 純化方法

  Crystallise curcumin from EtOH or acetic acid. [Beilstein 8 IV 3697.]

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クルクミン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

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