n-ブチルアミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

  H290：金属腐食のおそれ

  H302：飲み込むと有害

  H314：重篤な皮膚の薬傷?眼の損傷

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

n-ブチルアミン 価格

MSDS Information

• 1-Butanamine

n-ブチルアミン 化学特性,用途語,生産方法

• 外観

  無色～ほとんど無色, 澄明の液体

• 溶解性

  水, アルコール, エーテルと混和。水、エタノール及びアセトンに極めて溶けやすい。

• 用途

  界面活性剤?有機ゴム薬品?染料?医薬?農薬?原料、食品添加物、触媒

• 説明

  n-Butylamine is one of the four isomeric amines of butane, the others being sec-butylamine, tert-butylamine, and isobutylamine. It is a colourless to yellow liquid and is highly flammable. It is stable and incompatible with oxidising agents, aluminium, copper, copper alloys, and acids. n-Butylamine finds its uses in the manufacture of pesticides (such as thiocarbazides), pharmaceuticals, and emulsifiers. It is also a precursor for the manufacture of N,N′-dibutylthiourea, a rubber vulcanisation accelerator, and n-butylbenzenesulphonamide, a plasticiser of nylon.

• 化学的特性

  n-Butylamine is a derivative of ammonia in which one of the hydrogen atoms is replaced with an alkyl group of four carbons. As such, it reacts with water and acids to form bases and salts, respectively. Acting as a very weak acid, it can react with acyl halides, anhydrides, and esters. With carbon disulfide and carbon dioxide, it forms the butyl ammonium salt of dithiocarbamic and carbamic acids, respectively. With isocyanic acid and alkyl or aryl isocyanates, it forms substituted ureas. When reacted with nitrous acid, rc-butylamine forms butyl alcohol with the release of nitrogen (Schweizer et al 1978).
  In the presence of water, rc-butylamine may corrode some metals (General Electric Co 1986) and attack glass (Schweizer et al 1978). Liquid n-butylamine also will attack some forms of plastics, rubber, and coatings (NIOSH 1981).

• 物理的性質

  Butylamine has an ammoniacal odor (fishy, pungent). Clear, colorless liquid with a strong or pungent, ammonia-like odor. Slowly becomes pale yellow on prolonged storage. Experimentally determined detection and recognition odor threshold concentrations were 240 μg/m³ (80 ppb_v) and 720 μmg/m³ (240 ppb_v), respectively (Hellman and Small, 1974).

• 天然物の起源

  Reported found in mulberry leaves, kale, tomato, tilsit cheese, cheddar and other cheeses, caviar, fish, cooked chicken, cooked beef, beer, sherry and red wine.

• 使用

  n-Butylamine is used as an intermediatefor various products, including dyestuffs,pharmaceuticals, rubber chemical, synthetictanning agents, and emulsifying agents. It isused for making isocyanates for coatings.

• 製造方法

  Catalytic alkylation of ammonia with butyl alcohol.

• 調製方法

  n-Butylamine is usually manufactured by the catalytic alkylation of ammonia with butyl alcohol, or similarly from butyraldehyde and ammonia in the presence of Raney nickel. U.S. production in 1982 was approximately 1109 metric tons (SRI 1985). Some n-butylamine is also produced as a result of fertilizer manufacture, fish processing, rendering plant operations, and sewage treatment and has been reported to be a component of animal waste (Graedel 1978).

• 定義

  ChEBI: A primary aliphatic amine that is butane substituted by an amino group at position 1.

• 一般的な説明

  A clear colorless liquid with an ammonia-like odor. Flash point 10°F. Less dense (6.2 lb / gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.

• 空気と水の反応

  Highly flammable. Dissolves in water with evolution of heat. The resulting solutions are basic.

• 反応プロフィール

  N-BUTYL AMINE reacts violently with strong oxidizing agents and acids. Attacks copper and copper compounds [Handling Chemicals Safely 1980 p. 123]. Reacts with hypochlorites to give N-chloroamines which may be explosive when isolated [Bretherick 1979 p. 108].

• 危険性

  Skin irritant. Flammable, dangerous fire risk. Eye and upper respiratory tract irritant.

• 健康ハザード

  n-Butylamine is a severe irritant to the eyes,skin, and respiratory tract. Contact of theliquid with the skin and eyes can producesevere burns. Irritation effect on rabbits’ eyeswas as severe as that produced by ethylamine(ACGIH 1986). Exposure can cause irritationof the nose and throat, and at high concen trations, pulmonary edema. Scherberger andassociates (1960) have reported erythema ofthe face and neck occurring within 3 hoursafter exposure to n-butylamine, along with aburning and itching sensation.
  n-Butylamine is more toxic than is eithern-propylamine or ethylamine. A 4-hourexposure to 3000-ppm concentration in airwas lethal to rats. Toxic symptoms in animalsfrom ingestion include increased pulse rate,labored breathing, and convulsions. Cyanosisand coma can occur at near-lethal dose.
  LD50 value, oral (rats): 366 mg/kg
  LD50 value, skin (guinea pigs): 366 mg/kg.

• 化学反応性

  Reactivity with Water No reaction; Reactivity with Common Materials: May corrode some metals in presence of water; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

• 工業用途

  n-Butylamine is an important intermediate in the production of pharmaceuticals, dyestuffs, synthetic tanning agents, insecticides, emulsifying agents, rubber accelerators, vulcanizing agents, and antioxidants (HSDB 1988). A flavor ingredient in seafood and chocolate, n-butylamine is also reported to be used in alcoholic beverages, ice cream, candy, baked goods, gelatins, and puddings all at a concentration of 0.1 p.p.m. (Fenaroli 1975). It is estimated that 50% of the n-butylamine produced is used for rubber processing chemicals and 50% as an intermediate in pesticide production (SRI 1982).

• 職業ばく露

  Alert: (n-isomer): Possible risk of forming tumors, suspected of causing genetic defects, suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (sec-isomer): Drug. n-Butylamine is used in pharmaceuticals; dyestuffs, rubber, chemicals, emulsifying agents; photography, desizing agents for textiles; pesticides, and synthetic agents. sec-Butylamine is used as a fungistate. tert-Butylamine is used as a chemical intermediate in the production of tert-Butylaminoethyl methacrylate (a lube oil additive); as an intermediate in the production of rubber and in rust preventatives and emulsion deterrents in petroleum products. It is used in the manufacture of several drugs

• 発がん性

  The concentrated liquid produced severe eye damage and skin burns in animals.

• 環境運命予測

  Photolytic. Low et al. (1991) reported that the photooxidation of aqueous primary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
  Chemical/Physical. Reacts with mineral acids forming water-soluble salts.
  At an influent concentration of 1.0 g/L, treatment with GAC resulted in effluent concentration of 480 mg/L. The adsorbability of the carbon used was 103 mg/g carbon (Guisti et al., 1974).

• 代謝

  Considering the industrial importance of this amine, it is surprising that no thorough studies of its metabolism have been completed. Aliphatic amines, in general, are well-absorbed from the gut and respiratory tract and readily metabolised (Beard and Noe 1981; Magos and Manson 1983). After oral administration of n-butylamine hydrochloride to humans, little n-butylamine was recovered in the urine (Rechenberger 1940) suggesting that extensive metabolism occurs. Deamination of n-butylamine has been shown to occur in slices of rat liver and brain cortex (Pugh and Quastel 1937). It is assumed that monoamine oxidase plays a role in the detoxication process by catalyzing the deamination of n-butylamine to ammonia, hydrogen peroxide, and butyraldehyde. The ammonia produced is then converted to urea and the hydrogen peroxide is reduced by catalase. The aldehyde is probably converted to the corresponding carboxylic acid by aldehyde oxidase (Beard and Noe, 1981).

• Solubility in water

  Butylamine can dissolve in water by forming hydrogen bonds with water. Oxygen atoms in water hydrogen-bond to hydrogen atoms on the amine group.

• 貯蔵

  n-Butylamine should be protected against physical damage. Store in a cool, dry, wellventilated location, away from any area where the fi re hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfer to avoid static sparks.

• 輸送方法

  UN1125 n-Butylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material. UN2014 Isobutylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material

• 純化方法

  Dry it with solid KOH, K2CO3, LiAlH4, CaH2 or MgSO4, then reflux it with, and fractionally distil it from P2O5, CaH2, CaO or BaO. Further purification is by precipitation as the hydrochloride, m 213-213.5o, from ethereal solution by bubbling HCl gas into it. This is re-precipitated three times from EtOH by adding ether, followed by liberation of the free amine using excess strong base. The amine is extracted into ether, which is separated, dried with solid KOH, the ether removed by evaporation and then the amine is distilled. It is stored in a desiccator over solid NaOH [Bunnett & Davis J Am Chem Soc 82 665 1960, Lycan et al. Org Synth Coll Vol II 319 1943]. [Beilstein 4 IV 540.] SKIN IRRITANT.

• 不和合性

  May form explosive mixture with air. May accumulate static electrical charges, and may causeignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids, causing fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moisture. The tert-isomer will attack some forms of plastics

• 廃棄物の処理

  Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner andscrubber. All federal, state, and local environmental regulations must be observed.

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