イノシット

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H317：アレルギー性皮膚反応を起こすおそれ

  H319：強い眼刺激

  H412：長期的影響により水生生物に有害

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P333+P313：皮膚刺激または発疹が生じた場合：医師の診断/手当てを 受けること。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

イノシット 価格

MSDS Information

• 1,2,3,4,5,6-Cyclohexanehexol

イノシット 化学特性,用途語,生産方法

• 外観

  白色, 結晶～結晶性粉末

• 性質

  mp. 225～227 °C．二水塩結晶：mp. 218 °C．風解性．80 °C以上の水から無水晶．

• 定義

  本品は、次の化学式で表される環状六価アルコールである。

• 溶解性

  水に易溶。エタノールに微溶。エーテルに不溶。水に溶けやすく、エタノール及びエーテルに極めて溶けにくい。

• 解説

  イノシトールinositolとも呼ぶ。1871年にJ.F.vonリービヒにより，酵母などの発育促進因子としてその存在が予想され，20世紀に入り，その実体がシクロヘキサンヘキサオールであることがわかった。ビタミンB2群の一員で，欠乏によって脱毛などが起こる。また過コレステロール症に対する医薬品としても用いられる。9種の立体異性体が理論的に可能であるが，天然にはミオイノシット(ミオイノシトール)など4種が確認されているだけである。

  株式会社平凡社 世界大百科事典 第２版について　情報
  

• 無機性値/有機性値

  610/120

• 生物学的性質

  欠乏症：ネズミなどの動物に脱毛症，発育障害　機能：動植物のリン脂質の成分，グルコースから一部生成

• 化粧品の成分用途

  ヘアコンディショニング剤、保水剤

• 効能

  ビタミンB補充薬

• 応用

  イノシット,ビタミンB2群の一員で，欠乏によって脱毛などが起こる。また過コレステロール症に対する医薬品としても用いられる。9種の立体異性体が理論的に可能であるが，天然にはミオイノシット(ミオイノシトール)など4種が確認されているだけである。

• 説明

  Inositol (hexahydroxycyclohexane) is a widely distributed natural constituent of plant and animal tissues. The animal tissues richest in inositol are the brain, heart, stomach, kidney, spleen, and liver, where it occurs free or as a component of phospholipids. Among plants, cereals are rich sources of inositol, particularly in the form of polyphosphoric acid esters, called phytic acids. Although there are several possible optically active and inactive isomers, considerations of inositol as a food additive refer specifically to the optically inactive cis-1,2,3,5-trans-4,6-cyclohexanehexol, which is preferably designated myo-inositol. Pure inositol is a stable, white, sweet, crystalline compound. The Food Chemicals Codex specifies that it assay not less than 97.0 percent, melt between 224 and 227°, and contain not more than 3 ppm arsenic, 10 ppm lead, 20 ppm heavy metals (as Pb), 60 ppm sulfate, and 50 ppm chloride. 
  
  Inositol was thought for a time to be a vitamin because experimental animals on a synthetic diet developed clinical signs that were corrected by inositol supplementation. However, no cofactor or catalytic function for inositol has been found; it can be synthesized and occurs in relatively high concentration in animal tissues. These factors argue against its classification as a vitamin. A dietary requirement in man has not been established.

• 化学的特性

  Inositol is a cyclic carbohydrate with the molecular formula C₆H₁₂O₆ and a relative molecular mass of 180.16. It appears as white crystals or a white crystalline powder, is odourless, has a slightly sweet taste, readily absorbs moisture, and has a melting point of 220–225 °C and a boiling point of 319 °C. It is readily soluble in water, forming a neutral aqueous solution, and slightly soluble in organic solvents such as alcohol, glacial acetic acid, and glycerol. Research indicates that thermally fused inositol forms metastable amorphous crystals under freezing conditions.
  
  Containing six hydroxyl groups, inositol is also known as cyclohexanehexol. Theoretically, nine possible isomers exist: myo-inositol (MI), D-chiro-inositol (DCI), allo-inositol, cis-inositol, epi-inositol, muco-inositol, neo-inositol, scyllo-inositol, and L-chiro-inositol (LCI). Among these, DCI and LCI lack a plane of symmetry and are thus chiral molecules. Inositol typically exists in a free form within animal organisms, with MI and DCI performing multiple biological functions.

• 分布

  広く分布，植物種子リン酸エステル(フィチン酸)として多い

• 定義

  ChEBI: Inositol is an inositol having myo-configuration. It is a natural sugar found in cell membrane phospholipids, plasma lipoproteins, and (as the phosphate form) in the nucleus with potential chemopreventive properties. As one of a number of intracellular phosphate compounds, inositol is involved in cell signaling and may stimulate tumor cell differentiation.

• 一般的な説明

  Myoinositol is a stereoisomeric form of inositol, and is very often found in many plants and in tissues of animals and plants. It acts as a second messenger, thereby is very important for the signal pathways of cells. It generally finds application in being used as a natural insulin sensitizer in PCOS (Polycystic Ovarian Syndrome) patients. Myoinositol acts in a PCOS pathway by improving insulin sensitivity, thereby sequentially increasing intracellular glucose uptake.

• 概要

  イノシトールは通常meso-(myo-)イノシトールをさす．他に9種の異性体あり．動物組織，豆類に存在．リン脂質，リポタンパクの成分

• 純化方法

  Recrystallise myo-inositol from aqueous 50% ethanol or H2O forming a dihydrate, or anhydrous crystals from AcOH. The dihydrate is efflorescent and becomes anhydrous when heated at 100o . The anhydrous crystals are not hygroscopic. Its solubility in H2O at 25o is 14%, at 60o it is 28%; it is slightly soluble in EtOH but insoluble in Et2O. [Ballou & Anderson J Am Chem Soc 7 5 748 1953, Anderson & Wallis J Am Chem Soc 70 2931 1948, Beilstein 6 II 1157, 6 IV 7919.]

• Clinical claims and research

  Some researches have found that inositol enhanced cisplatin-induced histopathological improvements in the uterus and ovaries, raising progesterone and estradiol serum levels. Hence,  Inositol shield against cisplatin-related infertility by reducing oxidative stress and apoptosis in the uterus and ovaries. Inositol stereoisomers are naturally occurring molecules that readily cross the blood-brain barrier . It may represent a viable treatment for AD through the complexation of Abeta and attenuation of Abeta neurotoxic effects[1-2].

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イノシット 生産企業

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イノシット スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、Raman)

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