Uses
Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists
in vivo bioassays and in
in vivo antagonist and lipopolysaccharide stimulations.
Biochem/physiol Actions
Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
IC 50
5-HT
1A Receptor: 7.10 (pKd); 5-HT
1B Receptor: 7.28 (pKd); 5-HT
1C Receptor: 7.56 (pKd); 5-HT
1D Receptor: 6.99 (pKd); 5-HT
5A Receptor: 7.0 (pKd); 5-HT
5B Receptor: 7.8 (pKd); 5-HT
6 Receptor: 8.74 (pKd); 5-HT
7 Receptor: 8.99 (pKd); 5-HT
2A Receptor: 8.50 (pKi); 5-HT
2B Receptor: 8.68 (pKi); 5-HT
2C Receptor: 8.35 (pKi)