74611-28-2

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.

Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

5-HT_1A Receptor: 7.10 (pKd); 5-HT_1B Receptor: 7.28 (pKd); 5-HT_1C Receptor: 7.56 (pKd); 5-HT_1D Receptor: 6.99 (pKd); 5-HT_5A Receptor: 7.0 (pKd); 5-HT_5B Receptor: 7.8 (pKd); 5-HT₆ Receptor: 8.74 (pKd); 5-HT₇ Receptor: 8.99 (pKd); 5-HT_2A Receptor: 8.50 (pKi); 5-HT_2B Receptor: 8.68 (pKi); 5-HT_2C Receptor: 8.35 (pKi)